When should you drink Mexidol before or after meals? How to take Mexidol: before or after meals? Side effects from Mexidol and overdose

This is a Russian drug that is used for disorders of cerebral microcirculation. How to take Mexidol? In the morning or evening?

The instructions for use for the medicine do not contain information about the compatibility of the active ingredients of the drug with food. In this connection, Mexidol can be taken regardless of the food included in the daily menu.

In addition, among the positive aspects of the drug the following can be identified:

• no nausea after consumption;
• good tolerance;
• antioxidant effect on the body.

Indications

As a rule, Mexidol must be taken in the presence of the following conditions and diseases:

1. Various results of cerebral accidents (impaired microcirculation of the brain with damage to its tissue as a result of difficulty or complete cancellation of blood flow to its parts).
2. Head injury.
3. Diseases that are associated with vascular damage.
4. Weakness.
5. Ischemia (local decrease in blood supply, in most cases caused by a vascular factor, which leads to temporary dysfunction or damage to a tissue or organ).
6. Neurological diseases (a disease that develops as a result of damage to the brain and spinal cord, as well as peripheral nerve trunks and ganglia).
7. Lethargy.
8. General malaise.
9. Chronic stress (a serious illness that has even more negative consequences: various mental disorders and serious illnesses of internal organs).
10. Withdrawal syndrome in alcoholism (a consequence of depletion of resources of the whole organism in general and the liver in particular).
11. Vegetative-vascular dystonia (a complex of functional disorders based on a violation of the regulation of vascular tone by the autonomic nervous system).

In each situation, a specialist, taking into account all the characteristics of the patient’s body, develops a course of therapy that can achieve the fastest effect. In addition, the doctor will recommend how and at what time it is best to take Mexidol tablets.

Should I take the drug before or after meals? Read more about this.

Contraindications

Despite the huge range of actions, Mexidol cannot be used by all people. There are situations in which the use of the medicine will not bring the desired effect, for example:

1. Individual intolerance to substances.
2. "Interesting position" of a woman.
3. Breast-feeding.
4. Acute liver and kidney diseases.

Peculiarities

How to take Mexidol, before or after meals? Food does not affect the absorption of the drug in any way. The drug is an antioxidant drug; as a rule, it is used for disorders of the functioning of the brain.

If you read the instructions for use of Mexidol in more detail, it indicates only the dosages that can be taken per day, as well as the duration of therapy with this medication.

So how should you take Mexidol, before or after meals? The use of the drug is not tied to food intake, that is, a person can take it when it is convenient for him. The basic rule is compliance with the dosage and sequence of administration.

Interaction

If a patient has doubts about the use of any drug, it is best to consult a specialist. Doctors say that Mexidol tablets can be taken regardless of the time of eating.

The instructions for use of the drug "Mexidol" do not indicate any interactions of the active substance with food or other medications, which would lead to a decrease in the pharmacological effect of the former or an increase in its toxic effect on the patient's body.

Now you know how to take Mexidol. Before or after food, it doesn’t matter. The medicine can be taken at any time, regardless of diet.

"Mexidol" is well tolerated by patients and does not irritate the mucous cavity of the gastrointestinal tract. Nausea may occur extremely rarely, but it is not related to the peculiarities of use.

The only key is compliance with the dosage - the daily concentration of the active substance is 250-500 milligrams, which is equal to three to four tablets per day, which must be divided into two or three doses.

Registration number: LSR-002063/07 dated 08/09/2007
Trade name of the drug: Mexidol
INN or group name:
Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form: film-coated tablets

Compound:
Active substance: ethylmethylhydroxypyridine succinate - 125 mg, Excipients: lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description: The tablets are round, biconvex, film-coated, white to off-white in color.

Pharmacotherapeutic group: antioxidant agent.

ATX Code: N07XX

Pharmacological properties:

Pharmacodynamics.
Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)). The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes. The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins. The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol has a pronounced antitoxic effect in withdrawal symptoms. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Pharmacokinetics:
Rapidly absorbed when taken orally. The maximum concentration at doses of 400 - 500 mg is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, is formed in large quantities and is found in the urine 1 - 2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates. Tx/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications for use:

Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
Mild traumatic brain injury, consequences of traumatic brain injury;
Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);
Autonomic dystonia syndrome;
Mild cognitive disorders of atherosclerotic origin;
Anxiety disorders in neurotic and neurosis-like conditions;
Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;
Conditions after acute intoxication with antipsychotic drugs;
Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;
Impact of extreme (stress) factors.

Contraindications:

Acute liver and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Directions for use and dosage:

Orally, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets). Duration of treatment - 2 - 6 weeks; to relieve alcohol withdrawal - 5-7 days. Treatment is stopped gradually, reducing the dose over 2 to 3 days. The initial dose is 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase until a therapeutic effect is obtained. The maximum daily dose is 800 mg (6 tablets).

Side effect:

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Interaction with other drugs:

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

Special instructions:

Overdose:

In case of overdose, drowsiness may develop.

Release form: Film-coated tablets 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each along with instructions for use per pack. For hospital use Film-coated tablets 125 mg. 450 and 900 tablets in a plastic jar made of food grade plastic along with instructions for use in corrugated cardboard boxes.

Storage conditions: List B. Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date: 3 years. Do not use after the expiration date indicated on the pack.

Vacation conditions: On prescription

Manufacturer:

A: ZiO-Zdorovye CJSC, 142103, Moscow region, Podolsk, st. Zheleznodorozhnaya 2
B: CJSC ALSI-Pharma, CJSC ALSI Pharma, 129272, Moscow, Trifonovsky deadlock, 3,

Organization receiving claims: LLC NPK Pharmasoft 115280, Moscow, st. Avtozavodskaya, 22

In this article you can read the instructions for use of the drug Mexidol. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Mexidol in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Mexidol in the presence of existing structural analogues. Use for the treatment of encephalopathies of various origins, traumatic brain injuries, asthenic conditions and many other brain disorders in adults, children, as well as during pregnancy and lactation.

Mexidol- antioxidant drug.

Mexidol is an inhibitor of free radical processes and a membrane protector. It has antihypoxic, antistress, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics /neuroleptics).

The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases dopamine levels in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and LDL.

The anti-stress effect is manifested in the normalization of post-stress behavior, somato-vegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain.

Mexidol has a pronounced antitoxic effect in withdrawal symptoms. Eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Pharmacokinetics

After taking the drug orally in doses of 400-500 mg, it is quickly absorbed. Quickly distributed in organs and tissues. It is rapidly excreted in the urine, mainly in the form of metabolites and in small quantities unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug.

Indications

• consequences of acute cerebrovascular accidents, incl. after transient ischemic attacks, in the subcompensation phase as preventive courses;
• mild traumatic brain injury, consequences of traumatic brain injury;
• encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
• autonomic dystonia syndrome;
• mild cognitive disorders of atherosclerotic origin;
• anxiety disorders in neurotic and neurosis-like conditions;
• relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;
• conditions after acute intoxication with antipsychotic drugs;
• asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;
• exposure to extreme (stress) factors.

Release forms

Solution for intravenous and intramuscular administration (in injections (ampoules)) 50 mg/ml (5%).

Film-coated tablets 125 mg.

Instructions for use and dosage regimen

The drug is prescribed orally at 125-250 mg 3 times a day. The initial dose is 125-250 mg (1-2 tablets) 1-2 times a day with a gradual increase until a therapeutic effect is obtained. The maximum daily dose is 800 mg (6 tablets).

Duration of treatment is 2-6 weeks, for relief of alcohol withdrawal - 5-7 days.

Treatment is stopped gradually, reducing the dose over 2-3 days.

Side effect

• dyspepsia;
• allergic reactions.

Contraindications

• acute liver failure;
• acute renal failure;
• hypersensitivity to the drug.

Due to insufficient knowledge of the effect of the drug:

• childhood;
• pregnancy;
• lactation period (breastfeeding).

Use during pregnancy and breastfeeding

Mexidol is contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug's effect.

special instructions

Mexidol can be combined with all drugs used to treat somatic diseases.

Use in pediatrics

Mexidol is not prescribed to children due to insufficient knowledge of the drug's effect.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug interactions

When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants.

Mexidol reduces the toxic effect of ethyl alcohol (alcohol).

Analogues of the drug Mexidol

Structural analogues of the active substance:

• Medomexy;
• Mexidant;
• Mexico;
• Mexiprim;
• Mexicofin;
• Metostabil;
• Neurox;
• Cerecard;
• Ethylmethylhydroxypyridine succinate.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Recently, the increasing number of cerebrovascular diseases, including cerebral strokes, has led to the search for new effective methods for their treatment.

Mexidol is a domestic original drug of a new type, the mechanism of action of which is determined by its antioxidant and membrane-protective properties.

Pharmacodynamic effects

Mexidol is a new drug that has pharmacological effects at least at two levels: at the level of nerve cells and at the vascular level (which does not have analogues). At the same time, it has antioxidant and antihypoxic effects. In addition, this drug stabilizes cell membranes and has nootropic and anxiolytic effects.

The drug effectively helps, it is prescribed as a stress-protective medication, as well as for the prevention of many pathological conditions. The body becomes more resistant to unfavorable environmental conditions, while at the same time, the proper level of development of adaptive reactions is ensured.

Mexidol helps restore the cyclic sleep-wake mechanism, improve sleep quality, increase tolerance to physical activity, emotional stress and various conflict situations. The anxiolytic effect of the drug is manifested in a decrease in internal anxiety, worry and fear.

Course use of the drug helps restore the body, improves cognitive functions, memory and learning processes.

In addition, the drug has anticonvulsant activity and can be used to treat various forms of epilepsy (which analogues do not have, and because of this there is a need for the separate use of antiepileptic drugs).

What other effects does Mexidol have on the body? The antihypoxic effect is manifested in an increase in the number of surviving experimental animals during the action of various types of hypoxia on their body.

Apparently, these effects are associated with an increase in anaerobic glycolysis and the amount of ATP, so indications for use include ischemic disorders.

Why does the medicine include cognitive dysfunction and disorders of mnestic processes in its indications? It inhibits lipid peroxidation, helps modulate the activity of membrane-bound enzymes, improving the transport of mediators in axon terminals.

Mexidol helps reduce increased blood viscosity, reduce the tendency to platelet aggregation, and improve the functioning of cerebral vessels. In addition, it helps to activate the metabolic processes of the brain tissue itself.

Pharmacokinetics

After administration, the drug is distributed very quickly and is also very quickly eliminated from the body. After which, after 4 hours, drug metabolites are no longer identified in the urine.

The mechanism of metabolism occurs primarily in the liver with the formation of glucuronic conjugates, some of which are capable of exhibiting pharmacological activity.

Features of use

Before you start taking any medication, you should carefully study the indications and contraindications for its use.

The drug is indicated for patients of any age as a complex treatment for acute disorders of blood supply to the brain.

Indications also include the treatment of encephalopathy, mnestic disorders of circulatory or atherosclerotic origin, and vegetative-vascular dystonia. The use of Mexidol in tablets is effective for the treatment of neuroses, withdrawal syndrome, intoxication and poisoning with various substances.

If these groups of patients also have contraindications, then the decision on the possibility of prescribing it is made by the doctor.

Methods of administration and average dosages

The drug is administered enterally (tablets) and parenterally (injections): intravenously and intramuscularly. The amount of substance administered depends on the patient’s initial condition and clinical diagnosis. Intravenous (drip) infusion is carried out at a rate of 35-55 drops/min, intravenously (stream) is administered for 6-8 minutes.

If the infusion is administered intravenously, it is diluted in a sterile sodium chloride solution. It is better to use a starting dose not exceeding 100 mg. It is distributed into three administrations per day, always after meals. Then the dosage is gradually increased until a therapeutic effect occurs.

For the treatment of acute cerebrovascular accidents (of any type and location) as part of complex therapy, Mexidol can be administered intravenously (by injection) or taken in tablets after meals for 2-4 days, from 200 to 300 mg 1 time per day. Then they switch to intramuscular administration of 100 mg of the drug 3 times a day. The duration of treatment for acute cerebrovascular accident is 10-14 days.

A critically important point in the effectiveness of therapy for cerebral stroke is its timely initiation.

At the prehospital stage, as monotherapy, administration should begin no later than 4 hours after the accident (by an emergency physician at a dosage of 400 mg) and then the drug can be continued to be injected in the neurological department or intensive care ward (ampoules at a dose of 800 to 1200 mg day). After stabilizing the patient's condition, the drug should be taken in tablets (300-400 mg per day).

If there are no indications for further treatment, it is best to discontinue the drug gradually, after stabilization of the clinical condition and laboratory parameters.

The duration of treatment for patients suffering from neuroses or neurosis-like disorders, mental symptoms of organic origin, as well as those caused by impaired blood supply to the brain, ranges from 2 to 6 weeks.

In order to relieve withdrawal symptoms caused by alcohol consumption, the drug is used for 5-6 days. In the latter case, injections can be replaced with tablets. It would be correct to take 2 tablets 2 times a day after meals for the entire period of existence of the specified syndrome.

The drug is effective in treating complications of diabetes mellitus. The tablets reduce the level of atherogenic blood lipids, improve microcirculation in the vessels of the brain, helping to normalize blood glucose levels (take as in the treatment of withdrawal syndrome).

When is the drug contraindicated?

The drug is not recommended for injection in patients with allergic reactions, including those with a history of hypersensitivity to the components of the drug. Contraindications include acute disorders of the functional activity of the liver and kidneys.

There is no data regarding the effect on children, pregnant women and mothers breastfeeding, so the drug is most often not prescribed to these groups of patients. If there is no alternative, then it should be prescribed only when the expected benefit significantly outweighs the harm.

Side effects

A distinctive feature of Mexidol is its low toxicity, hence the low incidence of side effects. Therefore, there are few contraindications to the drug.

Studies have proven that when the dose of the administered drug exceeds the level of toxic effects, disturbances in motor activity and coordination of movements are not observed for a long time, drowsiness and depression of brain functions do not occur.

Among the side effects that can be observed when using the drug in therapeutic concentrations are dry mouth, nausea and drowsiness.

Special instructions for use

It is better not to prescribe Mexidol to patients with arterial hypertension or a critical course of hypertension. For this category of people, the drug is prescribed only after normalization of blood pressure and sedation.

Mexidol is used with caution in persons whose work involves driving vehicles or complex mechanisms and requires increased concentration and attention.

Overdose of the drug is rare. Treatment is symptomatic, aimed at its rapid removal from the body.

Dialysis detoxification methods are used for treatment; it is recommended to drink more fluids.

Drug interactions

The medicine reduces the toxic effect and side effects of ethyl alcohol on the body, and also long-term potentiates the effect of benzodiazepine anxiolytics and antiparkinsonian drugs.

Cost of the drug

The cost of the drug depends on the pharmacy network and dosage. On average, a package (tablets, 30 pcs) can be purchased from 290 to 350 rubles. Large packages (tablets, 50 pcs) can be purchased a little more expensive - 400-450 rubles. The injection form of the drug (ampoules of a 5% solution, 2 ml, 10 pcs) will cost 490-550 rubles, ampoules (20 pcs, 5 ml each) will cost around 1,500 rubles.

Mexidol is a highly effective drug with a very wide range of pharmacodynamic effects on the body. The side effects of the drug are minimal.

Due to its high efficiency (which its analogs do not have), the drug can be used to treat acute and chronic cerebral circulatory disorders. Injection forms of release (ampoules) allow you to start therapy immediately (if indicated).

When is medication prescribed in tablets? Most often, after infusion therapy, patients are transferred to taking medication in tablet form (for the purpose of maintenance therapy, as well as as prophylaxis), when adverse factors affect the body, after which their side effects are reduced.

Recently, more and more people have to find out what Mexidol helps with. This is due to the growing number of vascular problems for which the drug is used. In addition, the possibility of its use in sports medicine is being considered.

Mexidol - composition

There are tablet and ampoule versions of this medicine. The doctor chooses which drug Mexidol will be prescribed based on the indications and ease of use. The difference between the different release forms lies in the concentration of the active substance and the presence of auxiliary components. The latter must be paid attention to if there have been cases of intolerance to any pharmaceutical products.

Mexidol - tablets

The main active ingredient is ethylmethylhydroxypyridine succinate, it contains 125 mg, other dosages are not yet produced. The composition of Mexidol tablets includes:

• lactose monohydrate;
• carmellose sodium;
• Magnesium stearate.

The outer part is white or cream in color and consists of:

• talc;
• polyethylene glycol;
• titanium dioxide;
• polyvinyl alcohol.

Mexidol - ampoules

If your doctor has prescribed Mexidol, injections can be an alternative to taking pills. Options are produced with 250 and 100 mg of the main component. Moreover, its concentration in 1 ml is the same in both cases – 50 mg. The ampoules also contain:

• sodium metabisulfide;
• water for injections.

Mexidol - indications for use

The Russian-made medicine has a unique two-level effect, so it will not be possible to briefly describe what Mexidol helps with. It affects blood vessels and the condition of nerve cells, producing the following effects:

• antioxidant;
• membrane-protective;
• antihypoxic;
• anticonvulsant;
• nootropic;
• hypolipidemic;
• anxiolytic.

These properties provide an extensive list of disorders for which medicine is needed. Why Mexidol is prescribed in a particular case is determined by the doctor - different problems cannot be solved in the same way, in each regimen the drug performs its own function. For this reason, self-medication is prohibited - it can cause harm even if the recommended doses are followed. The main reasons for prescribing medication are:

• and their consequences;
• vegetative dystonia;
• asthenic reaction;
• the result of an acute lack of cerebral blood supply;
• cognitive impairment of atherosclerotic nature;
• withdrawal syndrome;
• strong stress factors;
• ischemia;
• inflammation of the peritoneal organs;
• poisoning with psychotropic drugs;
• prevention of somatic disorders under high loads.

Mexidol - side effects

Unlike other drugs that have a powerful effect, Mexidol causes almost no side effects. If the dosage remains adequate to the problem, the following are possible:

• dry mouth;
• desire to sleep;
• nausea.

The volume of the substance obtained depends on what Mexidol helps in a particular case, so you cannot change it yourself. This is explained not so much by the possibility of getting a negative reaction, but by a decrease in effectiveness, which will complicate treatment. The low toxicity of the drug allows you to exceed the dose for a long time without reducing motor activity, a strong desire to sleep, or deteriorating motor coordination or brain function. Because of this, there is a risk of not noticing problems and adjusting the therapeutic regimen too late, which will lead to the need for its revision.

Mexidol - contraindications

Due to its relative safety, the list of problems for which the use of such treatment is prohibited is surprisingly small. It includes:

• acute disorders of renal and hepatic functions;
• allergies and intolerance to any component.

Whether Mexidol can be taken by children, pregnant and nursing mothers is decided on a case-by-case basis. There have been no studies on this topic, so doctors avoid using the drug in these groups of people. In rare cases, the appointment may take place, but only if there is confidence that the risk of negative consequences is significantly lower than the expected benefit.

In case of arterial hypertension and crisis, use is carried out under strict control of the pressure level; the use of additional agents is not excluded. Also, caution should be observed when taking it if it is necessary to drive a car and perform complex, high-precision work that requires high concentration of attention. If negative reactions occur, the dosage is revised or the drug is completely discontinued.

Mexidol - application

There is no universal duration, volume and route of administration of the drug. This is due to an extensive list of problems, which Mexidol helps with. In case of acute disorders, daily injections of 400-1200 mg are preferred. A rate of 40-60 drops per minute is allowed; if jet delivery is selected, then the dose is administered no faster than 5-7 minutes. Cancellation is carried out gradually after all indicators return to normal.

If Mexidol tablets are prescribed, the attending physician must decide how to take it - before or after meals. The second option is standard in the treatment of cerebrovascular accidents. The daily dose is 200-300 mg, duration is 10-14 days. In other cases, the intake begins with 1-2 tablets with a gradual increase in their number in order to identify an individual reaction to the medicine.

How long can you take Mexidol?

Treatment regimens vary depending on the problem and the specific characteristics of the situation. The chosen form of the drug also has an impact. Mexidol intramuscularly or intravenously is rarely used for more than 10 days, and tablets can be prescribed for a period of 1-1.5 months, but there have been cases of administration for six months. How to take Mexidol is determined by the doctor; you cannot not follow his instructions by abruptly stopping or prolonging the use of the medicine.

Mexidol for VSD

If you ask a doctor what Mexidol helps with, one of the first to be named will be vegetative-vascular problems. A particularly striking effect is achieved during their paroxysmal course. Relieves the main symptoms, has a noticeable calming effect, and normalizes sleep. Prescribed 100-200 mg intravenously for a ten-day period. When receiving intramuscularly, a period of 15 days is recommended, after which they switch to tablets of 0.25-0.5 g per day in 2-3 doses, the entire course is 2-6 weeks. Treatment of VSD with Mexidol ends with a gradual dose reduction over the last 3 days.

Mexidol for cervical osteochondrosis

Depending on the phase of the disease, 200-400 mg in the form of injections is recommended for 10 days. Then patients are transferred to oral administration of 0.125 mg three times a day. Mexidol can be taken in this mode for 2-6 weeks. It stimulates poor blood circulation, restoring normal oxygen saturation and eliminating unpleasant symptoms. This helps alleviate the condition, but does not eliminate the need to eliminate the root cause.

Mexidol for migraines

Due to its antioxidant effects, ability to help blood flow and absorption of other medications, Mexidol can be recommended for headaches. It is important to find out its cause, because the symptom can be a manifestation of various diseases. After establishing the prerequisites, the dose of the drug and concomitant medications are determined. It is necessary to follow the recommendations to avoid negative effects.

Mexidol for epilepsy

It is used intravenously twice a day, 100 mg for 15 days. Then the same dose is administered intramuscularly for the same period. You need to understand what liquid Mexidol helps with in this case. It is not able to eliminate the disorder itself, but will support the main therapy. The drug has an anticonvulsant effect, helping to make symptoms less pronounced. Treatment with Mexidol will make it possible to reduce the side effects of other drugs without affecting their effectiveness.

Mexidol for concussion

The use is indicated for mild forms, the effectiveness has been clinically confirmed. Mexidol for dizziness and other symptoms of a concussion is prescribed up to 375 mg per day, administration lasts 28-30 days. It is used as part of complex therapy, in which it is recommended to include it from the very beginning. This provides the best effect, simplifying the correction of post-traumatic disorders. Thanks to multifactorial effects, it improves cell energy metabolism, inhibits oxidative processes and stimulates memory functions.

Mexidol for stroke

It is very important to start treatment early; no more than 4 hours after the incident is considered optimal. The emergency doctor should administer 400 mg, then in the intensive care or neurology ward, injections of 800-1200 mg per day are continued. Mexidol after a stroke, when the condition has stabilized, take 300-400 mg tablets. If the doctor decides that there are no indications for further use, then discontinuation is carried out slowly.

Mexidol for alcohol intoxication

Due to the ability to reduce the effects of ethanol, the drug is used for acute poisoning or treatment of addiction. This is what the drug Mexidol helps with in this case, it eliminates:

• toxic and neurological manifestations;
• memory impairment;
• problems perceiving information;
• anxiety;
• high excitability.

Mexidol for a hangover after prolonged intoxication is administered for 7 days at 100-400 mg per day. A wide spectrum of action helps to quickly relieve the main manifestations of withdrawal syndrome. A positive result is observed 1.5-2 hours after the first injection, and a stable result is achieved after 2-3 days. Patients note the following effects:

• reduction of anxiety;
• elimination of headaches;
• suppression of alcohol motivation;
• stimulation of concentration;
• relieving fear and tension;
• the appearance of a comfortable state;
• disappearance of hallucinations, nightmares and alcohol-related dreams;
• restoration of vigor and activity.

Good tolerability removes restrictions on use; negative manifestations quickly disappear spontaneously or upon discontinuation of the drug. In exceptional cases with alcoholism, patients noted the appearance of:

• weaknesses;
• bitterness and dry mouth;
• dizziness.

Mexidol - analogues

• Mexicor is effective for alcohol dependence and costs less.
• Mexidant - helps with alcohol abuse, brain tissue injuries and VSD.
• Medomexi – chronic fatigue syndrome, VSD, brain tissue damage and withdrawal symptoms.
• Mexiprim - stimulates metabolic processes and blood circulation, improves the functioning of the central nervous system.
• Cerecard is an analogue of Mexidol for cerebral and myocardial infarction, stroke, ischemia, atherosclerosis and vegetative-vascular dystonia.
• Meksifin – encephalopathy, extensive brain damage, alcoholism, atherosclerosis.
• Neurox - prescribed for VSD, chronic fatigue syndrome, atherosclerosis and central nervous system problems. The big advantage is that the cost is several times lower.
• Meksifan - used for acclimatization, nervous system disorders, chronic fatigue. It is easily tolerated regardless of age, and is prescribed even to newborns.

Antihypoxic.
. Nootropic effect.
. Membranoprotective.
. Anticonvulsant effect.
. Anxiolytic.

In addition, a course of Mexidol tablets increases the body's resistance to stress, as well as resistance to the negative effects of damaging factors and oxygen-dependent conditions (shock, hypoxia, acute vasospasms). Mexidol, taken in tablet form as prescribed by a specialist, repeatedly improves metabolic processes in brain tissue, restores full blood circulation, improves the rheological properties of blood, preventing significant platelet aggregation. A hypolipidemic effect was also noticed after a course of Mexidol.

The mechanism of action of the main component of the drug is based on antioxidant, antihypoxic and membrane-protective effects. Indications for taking Mexidol tablets will be:

Acute and long-term consequences after cerebral accidents.
. Mild forms of traumatic brain injury.
. Encephalopathies of combined genesis.
. Vegetative-vascular states.
. Cognitive disorders and conditions of atherosclerotic nature of mild and moderate severity.
. In complex anti-ischemic therapy.
. Asthenic conditions.
. Relief of various withdrawal syndromes.

Contraindications to taking the drug:

Increased individual susceptibility to constituent chemical elements.
. Acute liver and kidney failure.

Insufficient knowledge of the drug does not allow specialists to recommend it during pregnancy and lactation. The same rules apply to children: Mexidol tablets are not prescribed to children under twelve years of age.

The average price of Mexidol tablets 0.125 g (30 pcs.) is 245 rubles, the price of Mexidol tablets 0.125 g (50 pcs.) is 380 rubles.

Official instructions for use of the drug Mexidol (tablets)

Reviews and comments

Sergey S.

Office work does not allow you to follow all the recommendations of specialists on improving the health of the body: often take walks in the air, visit fitness centers and swimming pools. The brain is constantly under stress. As a result, I began to have problems with memory and sleep (I began to forget some information, did not get enough sleep, and when I woke up, I felt unusually tired). Having turned to a specialist, I was prescribed the medicine Mexidol in tablets, but refused the Mexidol injection because I did not have enough time. I learned that you need to take it regularly, three times a day. Immediately I asked what is the best way to take Mexidol tablets: before meals or after, because... I don’t always manage to have a snack at work. The doctor prescribed taking 3 tablets. per day after meals. After completing a course of treatment with Mexidol tablets, I had the best reviews - my memory gradually strengthened, my sleep improved, I again became a full-fledged employee at work, and not a sleeping owl.

Marina.

The modern information age does not allow our children to fully rest - they are exposed to too much information, which contributes to the appearance of such an unpleasant diagnosis as vegetative-vascular disorders. They can manifest themselves in different ways: panic attacks, tachycardia, fatigue, frequent causeless headaches, and the like. By adolescence, it can be quite difficult to cope with them. Not prescribing psychotropic drugs is dangerous. The imbalance in the body is especially noticeable in the off-season. Mexidol tablets come to the aid of specialists and parents. The instructions for Mexidol tablets describe in detail: how to take Mexidol, course duration, indications and contraindications. Reviews of taking Mexidol tablets may be different for everyone, but personally, it helped me and my child very well. On the advice of our specialist, he will continue to take courses of treatment with Mexidol.

Hope

With horror, I began to notice that my brain activity had somehow worsened: my friends were remembering the past, asking if I remember the events of five years ago, but I don’t remember! I don’t have time to see a specialist - I’m overloaded with work. I went online, visited several resources, and came across forums discussing Mexidol. I carefully studied the instructions for Mexidol tablets and read the information about analogues. I followed my friend’s advice and first underwent a course of treatment with Mexidol in ampoules, and then, to consolidate the effect, I took tablets for a month. There was no difference in the sensation - Mexidol both in tablets and in injections, I didn’t understand which was better. Reviews from Mexidol tablets were the most positive - no dizziness, no drowsiness, but only a significant improvement in memory and brain activity in general.

Vladimir Ilyin

I had severe pain in my neck and head due to osteochondrosis, and I had to go to the clinic. There, a neurologist prescribed me Mexidol tablets, 1 tablet 3 times a day, to drink for a month. After 2 weeks of taking it, my head and neck stopped hurting, and my general condition became a little better. Then I tried Mexidol injections for several days, in my opinion, the injections act faster and more effectively than tablets, but Mexidol tablets are cheaper.

To the question How prin. Mexidol (before, during or after meals)? Is it possible to apply it? simultaneously with Tanakan? Are there better drugs? Which? given by the author Vladimir Kudaev the best answer is Mexidol, a good drug (another similar Actovegin, about the same level). You can take it with tanakan. Take regardless of food.

Answer from 22 answers[guru]

Hello! Here is a selection of topics with answers to your question: As prin. Mexidol (before, during or after meals)? Is it possible to apply it? simultaneously with Tanakan? Are there better drugs? Which?

Answer from I-beam[newbie]
Method of administration and dose: IM or IV (stream or drip). When administered by infusion, the drug should be diluted in an isotonic sodium chloride solution.
Doses are selected individually depending on the pathology and severity of the patient's condition.
The recommended dose is 5-10 mg/kg/day, depending on the condition.
Mexidol is injected slowly over 1-3 minutes, dropwise at a rate of 40-60 drops per minute.
In the treatment of acute cerebrovascular accident, Mexidol is used intravenously in drops from 100 to 1000 mg/day, depending on the severity of the condition, for 10-14 days (the daily dose is divided into 2-4 administrations), then intravenously in a stream or i.v. m 200 mg 2 times a day for another 10-14 days.
For acute traumatic brain injury, Mexidol is administered intravenously at a dose of 100-1000 mg/day, depending on the severity of the injury and the patient’s condition. The daily dose is divided into 2-4 injections.
For encephalopathies in the decompensation phase, Mexidol is used intravenously in a stream or drip at a dose of 200-300 mg 2-3 times a day for 10-14 days, then intramuscularly at 200-300 mg/day for 10-14 days.
For course prophylaxis for encephalopathies of various origins, Mexidol is administered intramuscularly at a dose of 200 mg 1-2 times a day for 10-14 days. In the future, they switch to using it in tablet form.
For vertebrobasilar insufficiency in the decompensation phase, Mexidol is administered 200 mg 2-3 times a day intravenously or intravenously, for 10-15 days; in the subcompensation phase - 200 mg 1-2 times a day intravenously or intramuscularly for 10-14 days with a further transition to the tablet form; in the compensation phase (preventive course) - 100-200 mg (1-2 amp.) IM daily for 10-15 days or in tablet form.
Epilepsy and episyndromes: 200-400 mg 1-2 times a day intravenously for 10-15 days, followed by transition to long-term oral administration.
For cognitive disorders of atherosclerotic origin in elderly patients, neurotic and psychoorganic syndromes - IM at a dose of 100-300 mg/day for 14-30 days, followed by switching to tablet form.
For alcohol and drug intoxication - IV drip at a dose of 300-400 mg 2-3 times a day until the intoxication subsides.
For withdrawal syndromes (alcohol and drugs) - at a dose of 200-300 mg intravenously or intramuscularly 2 times a day for 5-7 days.
In case of acute intoxication with antipsychotic drugs - intravenous drip, in a daily dose of 400-800 mg, divided into 2 injections.
For asthenic disorders - at a dose of 100-200 mg/day IM daily for 10-15 days. Then they switch to tablet form.
In acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis), Mexidol is prescribed on the first day both in the preoperative and postoperative periods. The dose of the drug depends on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. For acute edematous (interstitial) pancreatitis - 200-600 mg 2-3 times a day intravenously and intramuscularly. For necrotizing pancreatitis of mild severity - 200-400 mg 2-3 times a day intravenously and intramuscularly. For necrotizing pancreatitis of moderate severity - 200-600 mg 2-3 times a day intravenously; in case of a severe course of the process, on the first day a pulse dose of 800 mg is prescribed, divided into 2 injections, then 300 mg 2 times a day with a gradual decrease in the daily dose. In case of extremely severe necrotizing pancreatitis, the initial dose is 800 mg/day until the manifestations of pancreatogenic shock are persistently relieved, when the condition stabilizes - 300-400 mg 2 times a day intravenously, with a gradual reduction in the daily dose.
Course therapy with Mexidol is completed gradually, reducing the dose of the drug over 2-3 days.

How to take Mexidol before or after meals is a question that worries patients in the first place. In order to avoid side effects, you must follow the instructions for use.

Abstract to the medicine

The instructions for the drug do not contain information about the compatibility of the active ingredients of the drug with food products. In this regard, Mexidol can be taken regardless of the food included in the daily menu. In addition, among the advantages of the drug, the following characteristics can be distinguished:

• no nausea after administration;
• well tolerated by patients;
• antioxidant effect on the body.

Indications for use

This medication can be recommended for use by specialists in various medical fields. As a rule, Mexidol should be taken if you have the following health problems:

• various consequences of brain accidents;
• head injuries;
• diseases associated with impaired vascular function;
• ischemia;
• neurological diseases;
• weakness, lethargy and general malaise.

In each case, a specialist, taking into account all the characteristics of the patient’s body, develops a course of treatment with which the most effective effect can be achieved. In addition, the doctor will advise how and at what time to take the tablets correctly - before or after meals.

Contraindications

Despite the wide range of effects, Mexidol cannot be taken by all patients. There are cases in which the use of the medication will not be beneficial and will not help cope with the disease:

• individual intolerance to components;
• pregnancy;
• lactation period;
• acute liver and kidney failure.

Application options and daily dose

The drug is available in 2 forms:

The dose of the drug, which is recommended for use during the day, is calculated individually in each case. It all depends on the patient’s age, the nature and stage of development of the disease. On average, a patient is recommended to take a dose of medication per day.

It is known that taking many medications on an empty stomach has a negative effect on the stomach and digestive system as a whole. To avoid this problem, Mexidol tablets should be taken after meals.

Similar drugs

There are a sufficient number of drugs whose composition is similar to Mexidol. Among its main substitutes are:

The drugs are produced in tablets or ampoules intended for injection.

In addition to the similarity in composition, there are medications that resemble Mexidol in the nature of their effect on the body:

How to take Mexidol tablets

The popular new generation drug Mexidol, which belongs to the group of new generation antioxidants, is designed to stop destructive processes in the human body. Therefore, you need to know how to take Mexidol tablets to restore and normalize metabolic processes in brain cells, so as not to harm the body.

Composition of the drug and scope of application

The active ingredient in Mexidol is ethylmethylhydroxypyridine succinate 125 mg, resulting in the following type of effect on the body:

• Hypoxia tolerance improves;
• Mental abilities and concentration improve;
• The body can more easily tolerate stressful situations of various types;
• The state of nervousness is relieved;
• The toxic effects of alcohol on the body are reduced;
• Blood circulation in the brain improves;
• Sleep, appetite and general condition of the body improves.

Mexidol tablets, according to the instructions attached to the drug, are indicated for use to prevent cell oxidation and stabilize the structure of intracellular membranes. Regular use of this drug prevents platelet aggregation, reduces cholesterol levels in the blood and prevents the development of degenerative processes, thereby slowing down the aging process of the body.

Release form

Mexidol is available on the pharmaceutical market in 2 dosage forms: tablets and ampoules.

For oral administration, the tablet form of this drug is used, biconvex in shape, in a white or cream-colored shell. Which are packaged in 10 pieces, in cell blisters.

To administer Mexidol intramuscularly or by infusion, the medicine is released in ampoules made of white or darkened glass. The solution, contained in an ampoule of 2–5 ml, is a colorless or slightly yellow liquid, odorless and contains 50 mg of ethylmethylhydroxypyridine succinate per 1 ml of solution. The drug is injected intramuscularly into the upper outer quadrant of the gluteal muscle.

Mexidol is stored in a dry, dark place, indoors with a maximum temperature increase of up to 25 ° C. If unpacked, Mexidol is stored for up to 3 years from the date of production indicated on the package.

Taking Mexidol and its dosage

Mexidol tablets should be taken one or two tablets 3 times a day, taking into account the individual tolerance of the drug, but without exceeding the maximum dose of 600 mg, most often the course of treatment with Mexidol takes into account taking the medication for 14 - 42 days. With a gradual exit from it, which involves a daily reduction in the daily dose of the drug.

Use of Mexidol for VSD

For vegetative-vascular dystonia, the drug is taken in tablets at a dose of 125–250 mg, up to 3 times a day, or according to a regimen drawn up by the attending physician, which takes into account the individual characteristics of the patient and allows to minimize side effects from the use of the drug.

If after taking the medicine the patient feels lethargic or persistent drowsiness, it is necessary to contact the attending physician to review the dosage of the medicine. To avoid negative consequences for the body, it is not recommended to stop taking the pills on your own.

After taking Mexilod, during the treatment of VSD, the patient experiences a significant improvement in the psychological state, aggressiveness disappears, the feeling of depression and oppression goes away, and recovery from a depressive state is accelerated.

Relieving alcohol withdrawal

To relieve alcohol withdrawal syndrome, it is better to take Mexidol tablets for 7 days, as a continuation of treatment, after a course of intramuscular injections. The doctor independently, based on the individual characteristics of the patient’s body, selects the dosage of the drug for the patient and prescribes a regimen for taking the pills. The medicine entering the patient’s body quickly relieves withdrawal symptoms, restores the psycho-emotional background, improves memory and promotes rapid cleansing of the body when ingesting ethanol.

Cerebral circulatory disorders

In case of circulatory disorders in the brain, an intravenous course of the drug is prescribed, which is administered for 10-14 days 2-4 times a day, in a volume not exceeding 500 mg, by drip method. After which, for 2 weeks the medicine is administered by intramuscular injection, 2-3 times a day, 200-250 mg of the drug.

Upon completion of the main stage of therapeutic treatment, the patient may be prescribed oral administration of the drug for prophylactic purposes. To find out how to drink Mexidol, you need to consult your doctor.

Medicines with a similar spectrum of action

Mexidol is an original medicinal product with a patented active ingredient; its analogues on the pharmaceutical market are:

And other not so widespread medications. Despite the fact that the medicine is not cheap, in order to avoid unwanted side effects, it is not recommended to independently replace it with analogue drugs that have similar therapeutic characteristics.

Side effect of Mexidol, with uncontrolled use

Uncontrolled oral intake of Mexidol can provoke the following undesirable sensations: heartburn, nausea, headache, belching, general physical weakness, upset stomach. In extremely rare cases, Mexidol can provoke a decrease in blood pressure, impaired motor coordination and emotional hyperreactivity.

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Only the most current official instructions for the use of medicines! Instructions for medications on our website are published unchanged in the form in which they are attached to the medications.

Mexidol ® tablets

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

INSTRUCTIONS for medical use of the drug Mexidol ®

Registration number: LSR/07 dated 08/09/2007

Trade name of the drug: Mexidol

Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form: film-coated tablets

Active substance: ethylmethylhydroxypyridine succinate mg, excipients: lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description: Tablets are round, biconvex, film-coated, from white to white with a creamy tint.

Pharmacotherapeutic group: antioxidant agent.

Pharmacological properties:

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)). The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes. The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins. The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol has a pronounced antitoxic effect in withdrawal symptoms. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Rapidly absorbed when taken orally. The maximum concentration at mg doses is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in urine immediately after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates. Tx/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications for use:

Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;

Mild traumatic brain injury, consequences of traumatic brain injury;

Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);

Autonomic dystonia syndrome;

Mild cognitive disorders of atherosclerotic origin;

Anxiety disorders in neurotic and neurosis-like conditions;

Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;

Conditions after acute intoxication with antipsychotic drugs;

Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;

Impact of extreme (stress) factors.

Contraindications:

Acute liver and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Directions for use and dosage:

Orally, mg 3 times a day; maximum daily dose of zamg (6 tablets). Duration of treatment: week; for relief of alcohol withdrawal days. Treatment is stopped gradually, reducing the dose over the course of days. The initial dose is 50 mg (1 - 2 tablets) once a day with a gradual increase until a therapeutic effect is obtained. Maximum daily dose of mg (6 tablets).

Side effect:

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Interaction with other drugs:

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

Special instructions:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose:

In case of overdose, drowsiness may develop.

Release form: Film-coated tablets, 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each along with instructions for use per pack. For hospital use Film-coated tablets 125 mg. 450 and 900 tablets in a plastic jar made of food grade plastic along with instructions for use in corrugated cardboard boxes.

Storage conditions: List B. Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 3 years. Do not use after the expiration date indicated on the pack.

Dispensing conditions: By prescription

A: ZiO-Zdorovye CJSC, Moscow region, Podolsk, st. Zheleznodorozhnaya 2

B: CJSC ALSI-Pharma, CJSC ALSI Pharma, Moscow, Trifonovsky deadlock, 3,

Organization receiving claims: LLC NPK Pharmasoft, Moscow, st. Avtozavodskaya, 22

Pharmgroup:

Therapeutic effect:

Reviews and comments

My baby is 8 months old

Anna Fri, 02/08/:49

My child is 8 months old, diagnosed with PPCNSL. The neurologist prescribed Mexidol 1/4 tablet 2 times a day, but the instructions say that Mexidol is contraindicated for children, since no studies have been conducted. Can a child have Mexidol or not?

The doctor may prescribe for the child

A doctor may prescribe a drug to a child if the expected benefit is greater than the risk. Follow the neurologist's prescription. The experience of using Mexidol in children in previous studies showed positive results in the treatment of childhood neurological diseases.

Take Mexidol tablets

Guest Fri, 02/08/:50

Should Mexidol tablets be taken before or after meals, is this not written in the instructions?

Taking Mexidol tablets is not

Taking Mexidol tablets does not depend on food intake.

Hello, I have VSD, and

Inna Fri, 02/08/:01

Hello, I have VSD and acute panic attacks, can I take Mexidol?

Mexidol has been successfully used

Mexidol is successfully used to treat manifestations of vegetative-vascular dystonia, including elements of panic attacks.

For a month I took

Tatyana Fri, 02/08/:16

For a month I took Mexidol tablets, 1 tablet. 3 times a day, after the course I found out that I was pregnant. I am very worried about whether taking this drug will affect the baby and the course of pregnancy.

Don't worry, it won't hurt.

Don't worry, it won't hurt. Mexidol is an antioxidant and contains succinate, which is functionally significant for many processes occurring in the body, in particular, being a substrate for increasing energy metabolism in cells.

My child is 2 years and 9 months old.

Svetlana Fri, 12/12/:18

My child is 2 years and 9 months old. The neurologist prescribed Mexidol, Valfen and Magne B6 for us to take for a month, mix all three drugs 1/3+ 1/3 +3 ml twice a day. This is due to the fact that the child cried in kindergarten, did not eat anything and could not get used to the kindergarten.

Please tell me this will not harm the child.

Such drugs are not

Such drugs are not prescribed simply because a child cries in kindergarten. An accurate diagnosis is needed.

And the child also rose

Svetlana Sat, 13/12/:00

And the child also started vomiting from anxiety, while crying, while eating. For 2 weeks.

After the doctor prescribed these drugs (Mexidol, Valfen and Magne B6), he ordered a fundus test - the result was normal, plus he didn’t prescribe anything else.

Please tell me what to do?

At this time we are not visiting the kindergarten, and everything is fine at home with the child.

If the child is healthy, there is no need

If the child is healthy, there is no need to stuff him with medications.

tell me which one it should be

Vladimir Thu, 02/04/:49

Tell me what the taste of Mexidol should be, I drank one package of tablets, they had no taste, I took another one, it tasted sour

The taste depends on the shell, in

The taste depends on the shell; normally it should not be there.

Likewise! My parents

Natalya Wed, 08/02/:47

Likewise! My parents took Mexidol for many years, but the last time the pills tasted salty! I asked the manufacturer a question and they wrote back that taste doesn’t matter. But still there are vague doubts, what if it’s a fake? How to find out. There are already 4 boxes lying around.

Hello! I was prescribed

Lara Sat, 11/07/:26

Hello! I was prescribed Mexidol, when I went to the pharmacy I read that it contains lactose, and I am allergic to it. To make an appointment with a doctor is a long wait. Tell me what can replace Mexidol.

Medomexi solution for

Medomexi solution for intravenous and intramuscular administration is a lactose-free analogue. Also look at the active ingredient: ethylmethylhydroxypyridine succinate, the list of analogues is at the end of the instructions, and in general, you can ask the pharmacist at the pharmacy about such a replacement

I took Mexidol in

Tatyana Fri, 25/09/:23

I took Mexidol from April to May for 1 month, is it possible to use it after 5.5 months if there are indications for this?

The drug must be prescribed by a doctor

The drug must be prescribed by a doctor during a face-to-face appointment, and he also prescribes the duration of treatment.

Good afternoon. I have

Olga Sat, 26/09/:02

Good afternoon. I'm 19 weeks pregnant and have severe headaches. The neurologist prescribed me Mexidol 1 tablet 3 times, take it for a month. The instructions say it is contraindicated to take during pregnancy. What effects can Mexidol have on a child?

The effect of the drug on the fetus is not

The effect of the drug on the fetus has not been studied, so pregnancy is listed as a contraindication. It's better to be safe than sorry.

My son has low platelets

Irina Sun, 22/11/:04

My son has low platelets, can we take Mexidol?

This is not

This is not a contraindication. Contraindication: children's age.

Application of Maximov for

Valentina. Fri, 05/02/:16

Is there a place to use Maksimov for left-sided facial motor tics?

Can Mexidol in injections

Olga Sat, 06/02/:53

Can Mexidol injections cause a miscarriage if the pregnancy was short?

The effect of the drug on

The effect of the drug during pregnancy has not been studied.

Good afternoon, tell me

Svetlana Tue, 09/02/:05

Good afternoon, please tell me whether it is possible to take Mexidol and gliatilin at the same time. A neurologist prescribed these medications to us; we are one year old. If not, please tell me what is better, thank you.

Can

These drugs do not interact with each other. For children only as prescribed by a doctor, after weighing the risks and expected benefits.

take before or after meals

Guest Tue, 15/03/:53

take before or after meals

Already answered the same question above

Guest Tue, 15/03/:11

The doctor has already answered the same question above.

If you miss a pill

Mark Thu, 04/07/:37

If you miss a Mexidol tablet, should you skip it or take a double one?

Take the next one as soon as

Take the next one as soon as you remember. No need to double.

Hello. The child is 11 months old.

Kukenova Dina Tue, 07/06/:03

Hello. The child is 11 months old. Diagnosis of perinatal CNS damage of hypoxic-ischemic origin, mild severity, late recovery period. The neuropathologist prescribed Mexidol 1/4 tablet 2 times a day. 2 months. Is it dangerous to drink it for so long?

Use of the drug in

The use of the drug in childhood has not been sufficiently studied. The doctor prescribes the dosage and timing, weighing the risks and benefits.

Child 6 years old, a year ago

Irina Thu, 30/06/:00

The child is 6 years old, stuttering began a year ago. A pediatric psychoneurologist prescribed magnesium B6 - 1 tablet per day, Mexidol - 0.5 tablets, glycine - 1 t. twice a day. It helped a year ago. Now there is practically no effect. Maybe I need to increase the dose?

Is it possible to take Mexidol?

Natalya Tue, 06/09/:14

Is it possible to take Mexidol at the same time as glycine?

The interaction of these

No interaction of these drugs has been noted.

I took a pill at 9am

Galina Thu, 15/09/:02

At 9 am I took a Betaserc tablet. I was prescribed Mexidol tablets. Is it possible to take Mexidol on the same day at 17:00? Please tell me.

there were no pills in the pharmacy -

flura Wed, 02/11/:54

There were no tablets at the pharmacy, so I bought them in ampoules - can I just drink them?

Sveta Fri, 18/11/:11

I took a course of one tablet per day, does it have an effect or must it be taken as written in the instructions. How often can I take Mexidol? Is it addictive?

There shouldn't be any habituation.

There shouldn't be any habituation. Take as prescribed by your doctor.

I want to say a huge thank you

Margarita Fri, 31/03/:09

I would like to say a huge thank you to the neurologist who prescribed me Mexidol. I’ll be honest, I really don’t trust all the pills, I read a lot of reviews, some praise, some don’t seem to feel anything, you don’t know whether to drink or not to drink, but my emotional health has already reached a critical point, chronic neurosis has already finished me off, Panic attacks also tormented me, I thought that I was almost in pre-stroke conditions, I lost my speech for half a minute, what strange reasoning, which I can’t remember later, in general, it’s not life, but hell. I bought the pills and started drinking. on the first day I drank 1 tablet in the morning and 1 tablet. in the evening, on the first day, I didn’t even understand such a quick result, my head became clear, the desire to live returned, I can’t even express all my emotions, we’ll see how it goes, I’ve only been drinking for 2 days, thanks again to the doctor, who, one might say, got me back on my feet , but I still don’t understand that such progress happened in one day, although the reviews write that Mexidol has a cumulative effect. That's how it happens.

Mexidol and Mexicor are one thing

Nadezhda Wed, 05/24/:00

Are Mexidol and Mexicor the same thing?

The active ingredient is the same

The active ingredient is the same.

Tell me, should I take it?

Ruslan Tue, 30/05/:18

Tell me, you need to take it exactly 3 times a day, i.e. every 8 hours, or maybe in the morning, afternoon, and evening? Thank you.

Any drug is desirable

It is advisable to take any drug at the most equal intervals of time, for example at 7, 15 and 23

Thanks good prepor

Ivan Mon, 14/08/:44

Thank you, good drug.

My son (15 years old) was prescribed

Nadezhda Thu, 12/10/:06

My son (15 years old) was prescribed Mexidol, 1 tablet twice a day. My son has VSD and astheno-neurotic syndrome. According to the instructions, you need to do it three times. How to use?

When receiving, always

When taking the drug, they are always guided by the doctor’s prescription, since the dosage is selected taking into account not only the diagnosis, but the characteristics of the patient - age, weight, test results, etc.

Mexidol analogue, which

Olga Thu, 12/10/:45

Please name an analogue of Mexidol that is cheaper!

Recently, more and more people have to find out what Mexidol helps with. This is due to the growing number of vascular problems for which the drug is used. In addition, the possibility of its use in sports medicine is being considered.

Mexidol - composition

There are tablet and ampoule versions of this medicine. The doctor chooses which drug Mexidol will be prescribed based on the indications and ease of use. The difference between the different release forms lies in the concentration of the active substance and the presence of auxiliary components. The latter must be paid attention to if there have been cases of intolerance to any pharmaceutical products.

Mexidol - tablets

The main active ingredient is ethylmethylhydroxypyridine succinate, it contains 125 mg, other dosages are not yet produced. The composition of Mexidol tablets includes:

• lactose monohydrate;
• carmellose sodium;
• Magnesium stearate.

The outer part is white or cream in color and consists of:

• talc;
• polyethylene glycol;
• titanium dioxide;
• polyvinyl alcohol.

Mexidol - ampoules

If your doctor has prescribed Mexidol, injections can be an alternative to taking pills. Options are produced with 250 and 100 mg of the main component. Moreover, its concentration in 1 ml is the same in both cases – 50 mg. The ampoules also contain:

• sodium metabisulfide;
• water for injections.

Mexidol - indications for use

The Russian-made medicine has a unique two-level effect, so it will not be possible to briefly describe what Mexidol helps with. It affects blood vessels and the condition of nerve cells, producing the following effects:

• antioxidant;
• membrane-protective;
• antihypoxic;
• anticonvulsant;
• nootropic;
• hypolipidemic;
• anxiolytic.

These properties provide an extensive list of disorders for which medicine is needed. Why Mexidol is prescribed in a particular case is determined by the doctor - different problems cannot be solved in the same way, in each regimen the drug performs its own function. For this reason, self-medication is prohibited - it can cause harm even if the recommended doses are followed. The main reasons for prescribing medication are:

• and their consequences;
• vegetative dystonia;
• asthenic reaction;
• the result of an acute lack of cerebral blood supply;
• cognitive impairment of atherosclerotic nature;
• withdrawal syndrome;
• strong stress factors;
• ischemia;
• inflammation of the peritoneal organs;
• poisoning with psychotropic drugs;
• prevention of somatic disorders under high loads.

Mexidol - side effects

Unlike other drugs that have a powerful effect, Mexidol causes almost no side effects. If the dosage remains adequate to the problem, the following are possible:

• dry mouth;
• desire to sleep;
• nausea.

The volume of the substance obtained depends on what Mexidol helps in a particular case, so you cannot change it yourself. This is explained not so much by the possibility of getting a negative reaction, but by a decrease in effectiveness, which will complicate treatment. The low toxicity of the drug allows you to exceed the dose for a long time without reducing motor activity, a strong desire to sleep, or deteriorating motor coordination or brain function. Because of this, there is a risk of not noticing problems and adjusting the therapeutic regimen too late, which will lead to the need for its revision.

Mexidol - contraindications

Due to its relative safety, the list of problems for which the use of such treatment is prohibited is surprisingly small. It includes:

• acute disorders of renal and hepatic functions;
• allergies and intolerance to any component.

Whether Mexidol can be taken by children, pregnant and nursing mothers is decided on a case-by-case basis. There have been no studies on this topic, so doctors avoid using the drug in these groups of people. In rare cases, the appointment may take place, but only if there is confidence that the risk of negative consequences is significantly lower than the expected benefit.

In case of arterial hypertension and crisis, use is carried out under strict control of the pressure level; the use of additional agents is not excluded. Also, caution should be observed when taking it if it is necessary to drive a car and perform complex, high-precision work that requires high concentration of attention. If negative reactions occur, the dosage is revised or the drug is completely discontinued.

Mexidol - application

There is no universal duration, volume and route of administration of the drug. This is due to an extensive list of problems, which Mexidol helps with. In case of acute disorders, daily injections of 400-1200 mg are preferred. A rate of 40-60 drops per minute is allowed; if jet delivery is selected, then the dose is administered no faster than 5-7 minutes. Cancellation is carried out gradually after all indicators return to normal.

If Mexidol tablets are prescribed, the attending physician must decide how to take it - before or after meals. The second option is standard in the treatment of cerebrovascular accidents. The daily dose is 200-300 mg, duration is 10-14 days. In other cases, the intake begins with 1-2 tablets with a gradual increase in their number in order to identify an individual reaction to the medicine.

How long can you take Mexidol?

Treatment regimens vary depending on the problem and the specific characteristics of the situation. The chosen form of the drug also has an impact. Mexidol intramuscularly or intravenously is rarely used for more than 10 days, and tablets can be prescribed for a period of 1-1.5 months, but there have been cases of administration for six months. How to take Mexidol is determined by the doctor; you cannot not follow his instructions by abruptly stopping or prolonging the use of the medicine.

Mexidol for VSD

If you ask a doctor what Mexidol helps with, one of the first to be named will be vegetative-vascular problems. A particularly striking effect is achieved during their paroxysmal course. Relieves the main symptoms, has a noticeable calming effect, and normalizes sleep. Prescribed 100-200 mg intravenously for a ten-day period. When receiving intramuscularly, a period of 15 days is recommended, after which they switch to tablets of 0.25-0.5 g per day in 2-3 doses, the entire course is 2-6 weeks. Treatment of VSD with Mexidol ends with a gradual dose reduction over the last 3 days.

Mexidol for cervical osteochondrosis

Depending on the phase of the disease, 200-400 mg in the form of injections is recommended for 10 days. Then patients are transferred to oral administration of 0.125 mg three times a day. Mexidol can be taken in this mode for 2-6 weeks. It stimulates poor blood circulation, restoring normal oxygen saturation and eliminating unpleasant symptoms. This helps alleviate the condition, but does not eliminate the need to eliminate the root cause.

Mexidol for migraines

Due to its antioxidant effects, ability to help blood flow and absorption of other medications, Mexidol can be recommended for headaches. It is important to find out its cause, because the symptom can be a manifestation of various diseases. After establishing the prerequisites, the dose of the drug and concomitant medications are determined. It is necessary to follow the recommendations to avoid negative effects.

Mexidol for epilepsy

It is used intravenously twice a day, 100 mg for 15 days. Then the same dose is administered intramuscularly for the same period. You need to understand what liquid Mexidol helps with in this case. It is not able to eliminate the disorder itself, but will support the main therapy. The drug has an anticonvulsant effect, helping to make symptoms less pronounced. Treatment with Mexidol will make it possible to reduce the side effects of other drugs without affecting their effectiveness.

Mexidol for concussion

The use is indicated for mild forms, the effectiveness has been clinically confirmed. Mexidol for dizziness and other symptoms of a concussion is prescribed up to 375 mg per day, administration lasts 28-30 days. It is used as part of complex therapy, in which it is recommended to include it from the very beginning. This provides the best effect, simplifying the correction of post-traumatic disorders. Thanks to multifactorial effects, it improves cell energy metabolism, inhibits oxidative processes and stimulates memory functions.

Mexidol for stroke

It is very important to start treatment early; no more than 4 hours after the incident is considered optimal. The emergency doctor should administer 400 mg, then in the intensive care or neurology ward, injections of 800-1200 mg per day are continued. Mexidol after a stroke, when the condition has stabilized, take 300-400 mg tablets. If the doctor decides that there are no indications for further use, then discontinuation is carried out slowly.

Mexidol for alcohol intoxication

Due to the ability to reduce the effects of ethanol, the drug is used for acute poisoning or treatment of addiction. This is what the drug Mexidol helps with in this case, it eliminates:

• toxic and neurological manifestations;
• memory impairment;
• problems perceiving information;
• anxiety;
• high excitability.

Mexidol for a hangover after prolonged intoxication is administered for 7 days at 100-400 mg per day. A wide spectrum of action helps to quickly relieve the main manifestations of withdrawal syndrome. A positive result is observed 1.5-2 hours after the first injection, and a stable result is achieved after 2-3 days. Patients note the following effects:

• reduction of anxiety;
• elimination of headaches;
• suppression of alcohol motivation;
• stimulation of concentration;
• relieving fear and tension;
• the appearance of a comfortable state;
• disappearance of hallucinations, nightmares and alcohol-related dreams;
• restoration of vigor and activity.

Good tolerability removes restrictions on use; negative manifestations quickly disappear spontaneously or upon discontinuation of the drug. In exceptional cases with alcoholism, patients noted the appearance of:

• weaknesses;
• bitterness and dry mouth;
• dizziness.

Mexidol - analogues

• Mexicor is effective for alcohol dependence and costs less.
• Mexidant - helps with alcohol abuse, brain tissue injuries and VSD.
• Medomexi – chronic fatigue syndrome, VSD, brain tissue damage and withdrawal symptoms.
• Mexiprim - stimulates metabolic processes and blood circulation, improves the functioning of the central nervous system.
• Cerecard is an analogue of Mexidol for cerebral and myocardial infarction, stroke, ischemia, atherosclerosis and vegetative-vascular dystonia.
• Meksifin – encephalopathy, extensive brain damage, alcoholism, atherosclerosis.
• Neurox - prescribed for VSD, chronic fatigue syndrome, atherosclerosis and central nervous system problems. The big advantage is that the cost is several times lower.
• Meksifan - used for acclimatization, nervous system disorders, chronic fatigue. It is easily tolerated regardless of age, and is prescribed even to newborns.

Recently, the increasing number of cerebrovascular diseases, including cerebral strokes, has led to the search for new effective methods for their treatment.

Mexidol is a domestic original drug of a new type, the mechanism of action of which is determined by its antioxidant and membrane-protective properties.

Pharmacodynamic effects

Mexidol is a new drug that has pharmacological effects at least at two levels: at the level of nerve cells and at the vascular level (which does not have analogues). At the same time, it has antioxidant and antihypoxic effects. In addition, this drug stabilizes cell membranes and has nootropic and anxiolytic effects.

The drug effectively helps, it is prescribed as a stress-protective medication, as well as for the prevention of many pathological conditions. The body becomes more resistant to unfavorable environmental conditions, while at the same time, the proper level of development of adaptive reactions is ensured.

Mexidol helps restore the cyclic sleep-wake mechanism, improve sleep quality, increase tolerance to physical activity, emotional stress and various conflict situations. The anxiolytic effect of the drug is manifested in a decrease in internal anxiety, worry and fear.

Course use of the drug helps restore the body, improves cognitive functions, memory and learning processes.

In addition, the drug has anticonvulsant activity and can be used to treat various forms of epilepsy (which analogues do not have, and because of this there is a need for the separate use of antiepileptic drugs).

What other effects does Mexidol have on the body? The antihypoxic effect is manifested in an increase in the number of surviving experimental animals during the action of various types of hypoxia on their body.

Apparently, these effects are associated with an increase in anaerobic glycolysis and the amount of ATP, so indications for use include ischemic disorders.

Why does the medicine include cognitive dysfunction and disorders of mnestic processes in its indications? It inhibits lipid peroxidation, helps modulate the activity of membrane-bound enzymes, improving the transport of mediators in axon terminals.

Mexidol helps reduce increased blood viscosity, reduce the tendency to platelet aggregation, and improve the functioning of cerebral vessels. In addition, it helps to activate the metabolic processes of the brain tissue itself.

Pharmacokinetics

After administration, the drug is distributed very quickly and is also very quickly eliminated from the body. After which, after 4 hours, drug metabolites are no longer identified in the urine.

The mechanism of metabolism occurs primarily in the liver with the formation of glucuronic conjugates, some of which are capable of exhibiting pharmacological activity.

Features of use

Before you start taking any medication, you should carefully study the indications and contraindications for its use.

The drug is indicated for patients of any age as a complex treatment for acute disorders of blood supply to the brain.

Indications also include the treatment of encephalopathy, mnestic disorders of circulatory or atherosclerotic origin, and vegetative-vascular dystonia. The use of Mexidol in tablets is effective for the treatment of neuroses, withdrawal syndrome, intoxication and poisoning with various substances.

If these groups of patients also have contraindications, then the decision on the possibility of prescribing it is made by the doctor.

Methods of administration and average dosages

The drug is administered enterally (tablets) and parenterally (injections): intravenously and intramuscularly. The amount of substance administered depends on the patient’s initial condition and clinical diagnosis. Intravenous (drip) infusion is carried out at a rate of 35-55 drops/min, intravenously (stream) is administered for 6-8 minutes.

If the infusion is administered intravenously, it is diluted in a sterile sodium chloride solution. It is better to use a starting dose not exceeding 100 mg. It is distributed into three administrations per day, always after meals. Then the dosage is gradually increased until a therapeutic effect occurs.

For the treatment of acute cerebrovascular accidents (of any type and location) as part of complex therapy, Mexidol can be administered intravenously (by injection) or taken in tablets after meals for 2-4 days, from 200 to 300 mg 1 time per day. Then they switch to intramuscular administration of 100 mg of the drug 3 times a day. The duration of treatment for acute cerebrovascular accident is 10-14 days.

A critically important point in the effectiveness of therapy for cerebral stroke is its timely initiation.

At the prehospital stage, as monotherapy, administration should begin no later than 4 hours after the accident (by an emergency physician at a dosage of 400 mg) and then the drug can be continued to be injected in the neurological department or intensive care ward (ampoules at a dose of 800 to 1200 mg day). After stabilizing the patient's condition, the drug should be taken in tablets (300-400 mg per day).

If there are no indications for further treatment, it is best to discontinue the drug gradually, after stabilization of the clinical condition and laboratory parameters.

The duration of treatment for patients suffering from neuroses or neurosis-like disorders, mental symptoms of organic origin, as well as those caused by impaired blood supply to the brain, ranges from 2 to 6 weeks.

In order to relieve withdrawal symptoms caused by alcohol consumption, the drug is used for 5-6 days. In the latter case, injections can be replaced with tablets. It would be correct to take 2 tablets 2 times a day after meals for the entire period of existence of the specified syndrome.

The drug is effective in treating complications of diabetes mellitus. The tablets reduce the level of atherogenic blood lipids, improve microcirculation in the vessels of the brain, helping to normalize blood glucose levels (take as in the treatment of withdrawal syndrome).

When is the drug contraindicated?

The drug is not recommended for injection in patients with allergic reactions, including those with a history of hypersensitivity to the components of the drug. Contraindications include acute disorders of the functional activity of the liver and kidneys.

There is no data regarding the effect on children, pregnant women and mothers breastfeeding, so the drug is most often not prescribed to these groups of patients. If there is no alternative, then it should be prescribed only when the expected benefit significantly outweighs the harm.

Side effects

A distinctive feature of Mexidol is its low toxicity, hence the low incidence of side effects. Therefore, there are few contraindications to the drug.

Studies have proven that when the dose of the administered drug exceeds the level of toxic effects, disturbances in motor activity and coordination of movements are not observed for a long time, drowsiness and depression of brain functions do not occur.

Among the side effects that can be observed when using the drug in therapeutic concentrations are dry mouth, nausea and drowsiness.

Special instructions for use

It is better not to prescribe Mexidol to patients with arterial hypertension or a critical course of hypertension. For this category of people, the drug is prescribed only after normalization of blood pressure and sedation.

Mexidol is used with caution in persons whose work involves driving vehicles or complex mechanisms and requires increased concentration and attention.

Overdose of the drug is rare. Treatment is symptomatic, aimed at its rapid removal from the body.

Dialysis detoxification methods are used for treatment; it is recommended to drink more fluids.

Drug interactions

The medicine reduces the toxic effect and side effects of ethyl alcohol on the body, and also long-term potentiates the effect of benzodiazepine anxiolytics and antiparkinsonian drugs.

Cost of the drug

The cost of the drug depends on the pharmacy network and dosage. On average, a package (tablets, 30 pcs) can be purchased from 290 to 350 rubles. Large packages (tablets, 50 pcs) can be purchased a little more expensive - 400-450 rubles. The injection form of the drug (ampoules of a 5% solution, 2 ml, 10 pcs) will cost 490-550 rubles, ampoules (20 pcs, 5 ml each) will cost around 1,500 rubles.

Mexidol is a highly effective drug with a very wide range of pharmacodynamic effects on the body. The side effects of the drug are minimal.

Due to its high efficiency (which its analogs do not have), the drug can be used to treat acute and chronic cerebral circulatory disorders. Injection forms of release (ampoules) allow you to start therapy immediately (if indicated).

When is medication prescribed in tablets? Most often, after infusion therapy, patients are transferred to taking medication in tablet form (for the purpose of maintenance therapy, as well as as prophylaxis), when adverse factors affect the body, after which their side effects are reduced.

Mexidol analogues

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

Registration number:
LSR-002063/07 dated 08/09/2007

Trade name of the drug:
Mexidol

Chemical rational name:
2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form:
film-coated tablets

Active substance:
ethylmethylhydroxypyridine succinate - 125 mg, excipients:
lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description:
The tablets are round, biconvex, film-coated, white to off-white in color.

Pharmacotherapeutic group:
antioxidant agent.

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)).

The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission.

Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins.

The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol has a pronounced antitoxic effect in withdrawal symptoms.

It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Rapidly absorbed when taken orally. The maximum concentration at doses of 400 - 500 mg is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified:

3-hydroxypyridine phosphate - is formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, is formed in large quantities and is found in the urine 1 - 2 days after administration; 3rd - excreted in large quantities in the urine;

4th and 5th - glucuron conjugates. Tx/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;

Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);

Autonomic dystonia syndrome;

Mild cognitive disorders of atherosclerotic origin;

Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;

Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;

Impact of extreme (stress) factors.

Acute liver and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Orally, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets). Duration of treatment - 2 - 6 weeks; to relieve alcohol withdrawal - 5-7 days. Treatment is stopped gradually, reducing the dose over 2 to 3 days. The initial dose is 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase until a therapeutic effect is obtained. The maximum daily dose is 800 mg (6 tablets).

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

In case of overdose, drowsiness may develop.

Release form:
Film-coated tablets 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each along with instructions for use per pack.

Storage conditions:
List B. Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date:
3 years. Do not use after the expiration date indicated on the pack.

Vacation conditions:
On prescription

A: ZiO-Zdorovye CJSC, 142103, Moscow region, Podolsk, st. Zheleznodorozhnaya 2

B: CJSC ALSI-Pharma, CJSC ALSI Pharma, 129272, Moscow, Trifonovsky deadlock, 3,

Organization receiving claims: LLC NPK Pharmasoft 115280, Moscow, st. Avtozavodskaya, 22

The popular new generation drug Mexidol, which belongs to the group of new generation antioxidants, is designed to stop destructive processes in the human body. Therefore, you need to know how to take Mexidol tablets to restore and normalize metabolic processes in brain cells, so as not to harm the body.

The active ingredient in Mexidol is ethylmethylhydroxypyridine succinate 125 mg, resulting in the following type of effect on the body:

• Hypoxia tolerance improves;
• Mental abilities and concentration improve;
• The body can more easily tolerate stressful situations of various types;
• The state of nervousness is relieved;
• The toxic effects of alcohol on the body are reduced;
• Blood circulation in the brain improves;
• Sleep, appetite and general condition of the body improves.

Mexidol tablets, according to the instructions attached to the drug, are indicated for use to prevent cell oxidation and stabilize the structure of intracellular membranes. Regular use of this drug prevents platelet aggregation, reduces cholesterol levels in the blood and prevents the development of degenerative processes, thereby slowing down the aging process of the body.

Before use, you should consult your doctor to determine if there are any contraindications for use. It is strictly forbidden to administer medicine to patients with the following diagnoses:

• Acute renal failure
• Acute liver failure
• Increased hypersensitivity to the main ingredient of the drug or to auxiliary components

An overdose of Mexidol may cause stomach pain and other dyspeptic disorders.

Mexidol usually has an easy effect on the body without causing side effects. Possible negative manifestations may occur due to individual intolerance. In this case, an allergic reaction to the administered drug may occur.

Failure to comply with the prescribed individual dosage leads to a dyspeptic reaction of the body to the administered drug.

• Anticonvulsant;
• Antioxidant;
• Nootropic;
• Anxiolytic;
• Antihypoxic;
• Memranoprotective;
• Hypolipidemic.

• Hangover syndrome caused by prolonged consumption of alcoholic beverages. It is characterized by mental and neurological signs of manifestation;
• Neurosis and anxiety disorders;
• Serious disruptions in the blood flow to the brain;
• Head injuries. Mexidol's indications describe its effectiveness in relieving swelling and relieving symptoms after injuries;
• Insufficiency of cerebral circulation, which gradually progresses, for example, with;
• Vegetative vascular dystonia;
• Cognitive disorders, manifested in slow reaction, poor memory and decreased mental abilities;
• Myocardial infarction in the acute stage. In this case, Mexidol is prescribed in the first days after the incident, mainly in the form of droppers;
• Primary open-angle glaucoma;
• General intoxication of the body resulting from antipsychotic medications taken, for example, Haloperidol;
• Acute stage of the inflammatory process in the abdominal cavity, which is characterized by the release of pus, for example, pancreatitis and peritonitis;
• Epilepsy attacks;
• Parkinsonian syndrome. In Parkinson's disease, the intensity of symptoms decreases significantly.

• To treat weakened blood flow in the brain, the drug is administered once a day. The duration of the course is strictly individual;
• In case of disruptions in cerebral circulation, Mexidol is administered 2-3 times a day for 2 weeks;
• The course of treatment for cognitive disorders and anxiety is 14 days. The drug is used once a day;
• For hangovers and drug addiction, 2-3 injections are usually given per day and the drug is discontinued when the desired result is achieved;
• In the presence of pathological changes in the brain resulting from injury or illness. In this case, drip administration of the drug is used, and the course duration is approximately 14 days;
• Mexidol for epilepsy is administered once a day for 2 weeks.

• Mexicor is effective for alcohol dependence and costs less.
• Mexidant - helps with alcohol abuse, brain tissue injuries and VSD.
• Medomexi – chronic fatigue syndrome, VSD, brain tissue damage and withdrawal symptoms.
• Mexiprim - stimulates metabolic processes and blood circulation, improves the functioning of the central nervous system.
• Cerecard is an analogue of Mexidol for cerebral and myocardial infarction, stroke, ischemia, atherosclerosis and vegetative-vascular dystonia.
• Meksifin – encephalopathy, extensive brain damage, alcoholism, atherosclerosis.
• Neurox - prescribed for VSD, chronic fatigue syndrome, atherosclerosis and central nervous system problems. The big advantage is that the cost is several times lower.
• Meksifan - used for acclimatization, nervous system disorders, chronic fatigue. It is easily tolerated regardless of age, and is prescribed even to newborns.

• Impaired cognitive function;
• Disturbed systemic circulation of the cerebral cortex and not only;
• Nervous disorders with panic attacks, anxiety;
• Open angle glaucoma;
• Insufficient nutrition of brain tissue.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible with Mexidol.

Overdose

Mexidol tablets are safe to use; cases of overdose are extremely rare. In case of overdose, general weakness or drowsiness may develop.

Mexidol is a new drug that has pharmacological effects at least at two levels: at the level of nerve cells and at the vascular level (which does not have analogues). At the same time, it has antioxidant and antihypoxic effects. In addition, this drug stabilizes cell membranes and has nootropic and anxiolytic effects.

The drug effectively helps, it is prescribed as a stress-protective medication, as well as for the prevention of many pathological conditions. The body becomes more resistant to unfavorable environmental conditions, while at the same time, the proper level of development of adaptive reactions is ensured.

Mexidol helps restore the cyclic sleep-wake mechanism, improve sleep quality, increase tolerance to physical activity, emotional stress and various conflict situations. The anxiolytic effect of the drug is manifested in a decrease in internal anxiety, worry and fear.

In addition, the drug has anticonvulsant activity and can be used to treat various forms of epilepsy (which analogues do not have, and because of this there is a need for the separate use of antiepileptic drugs).

What other effects does Mexidol have on the body? The antihypoxic effect is manifested in an increase in the number of surviving experimental animals during the action of various types of hypoxia on their body.

Apparently, these effects are associated with an increase in anaerobic glycolysis and the amount of ATP, so indications for use include ischemic disorders.

Why does the medicine include cognitive dysfunction and disorders of mnestic processes in its indications? It inhibits lipid peroxidation, helps modulate the activity of membrane-bound enzymes, improving the transport of mediators in axon terminals.

Mexidol helps reduce increased blood viscosity, reduce the tendency to platelet aggregation, and improve the functioning of cerebral vessels. In addition, it helps to activate the metabolic processes of the brain tissue itself.

Pharmacokinetics

After administration, the drug is distributed very quickly and is also very quickly eliminated from the body. After which, after 4 hours, drug metabolites are no longer identified in the urine.

The mechanism of metabolism occurs primarily in the liver with the formation of glucuronic conjugates, some of which are capable of exhibiting pharmacological activity.

The drug has pharmacological actions that are significant for the body and almost no

There are no adverse reactions and complications.

Therapeutic effects
are caused by the effect of the active substance of the drug on the central and autonomic nervous system and blood vessels.

Main properties of Mexidol:

• membrane stabilizer,
• inhibitor of the formation of free radicals,
• antihypoxant - (saturates the blood with oxygen),
• nootropic - (improves memory),
• tranquilizer - (relieves anxiety),
• increases the body's stability in conditions of hypoxia, ischemia, intoxication, and has an anticonvulsant effect.

Free radicals destroy cell walls or membranes, and then intracellular organelles, thereby triggering a mechanism for reducing immunity and the development of diseases dangerous to health.

Mexidol as a strong antioxidant
, suppresses the formation of free radicals and protects cells from their destructive effects. Under the influence of the drug, cell membranes are stabilized, the synthesis of nucleic acids and ATP is activated, blood counts, microcirculation and rheological properties improve, and cholesterol decreases.

By restoring blood circulation, blood supply and improving metabolic processes, dystrophic and morphological changes in all parts of the brain are reduced. In ischemic areas of the heart, the function of cardiomyocytes is preserved, and myocardial contractility is normalized. The processes of excitation and inhibition are balanced, the cyclical processes of sleep and wakefulness are restored, and the ability to learn and remember improves.

One of the most important properties of Mexidol is its strong antitoxic effect, which is especially evident in cases of alcohol intoxication and poisoning.

In addition, the drug increases the production of the neurotransmitter dopamine, which actively affects mood, causes feelings of pleasure, increases physical activity, and plays the role of an adaptogen in various stressful situations.

Mexidol is highly bioavailable, quickly absorbed and distributed in the blood to organs and tissues. It is destroyed in the liver into metabolites, excreted after 5-6 hours in the urine in the form of metabolites and in small quantities unchanged. The half-life is from 2 to 3 hours.

Usually, Mexidol does not cause side effects and this is possible mainly when used incorrectly. In rare cases, after using the solution, the following body reactions are observed:

• Nausea;
• Sleep disorders;
• Dry mouth;
• Allergic manifestations.

Medicine in the form of tablets sometimes provokes the development of the following pathological phenomena:

• Abdominal pain;
• Depressive state;
• Belching;
• Allergy;
• Nausea;
• Stool disorders;
• Heartburn;
• Loss of appetite;
• Weakness.

Sometimes patients experience surges in blood pressure (mostly a decrease), disruptions in coordination of movements and outbursts of emotions. Any form of the drug can affect the development of such pathological processes.

When is the drug contraindicated?

The drug enhances the effect of tranquilizers and pain relievers. Affects obtaining an improved result after the administration of anticonvulsants. Reduces the effect of ethyl alcohol on the body.

The drug is not recommended for injection in patients with allergic reactions, including those with a history of hypersensitivity to the components of the drug. Contraindications include acute disorders of the functional activity of the liver and kidneys.

There is no data regarding the effect on children, pregnant women and mothers breastfeeding, so the drug is most often not prescribed to these groups of patients. If there is no alternative, then it should be prescribed only when the expected benefit significantly outweighs the harm.

Side effects

A distinctive feature of Mexidol is its low toxicity, hence the low incidence of side effects. Therefore, there are few contraindications to the drug.

Among the side effects that can be observed when using the drug in therapeutic concentrations are dry mouth, nausea and drowsiness.

Overdose and additional instructions

Influence on the ability to drive vehicles and operate machinery. During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Nausea, dry mouth, and drowsiness may likely occur. Allergic reactions are possible.

special instructions

In cases of individual hypersensitivity of patients to the components of the drug, allergic reactions are possible. Patients who drive cars need special attention.

There are no peculiarities observed with the parallel use of several drugs.

Mexidol combines quite well with other medications.

Has the ability to reduce the toxic effect of ethyl alcohol.

If necessary, can be taken after drinking alcohol.

The drug can increase resistance to damaging influences (hypoxia, ischemia, shock, cerebral circulatory disorders, intoxication with alcoholic beverages or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. The activity of membrane enzymes and receptor complexes is also modulated, which improves the functioning of brain cell membranes.

Mexidol is able to reduce platelet aggregation, thereby improving the rheological properties of blood. Stabilizes blood cell membranes during hemolytic processes. Has a mild lipid-lowering effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and dystrophic disorders in brain structures. It has a good antitoxic effect during alcohol abuse, including during abstinence.

Reduces the manifestations of acute alcohol intoxication, normalizes behavior, and relieves cognitive impairment due to chronic alcohol consumption. Mexidol can enhance the effect of tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants, which, when taken together, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetically, Mexidol tablets are well absorbed when taken orally. It is quickly distributed throughout organs and tissues, the average duration of action of Mexidol is about 4-5 hours. Metabolized in the liver into 5 metabolites, pharmacologically active metabolites are determined in the urine for up to 48 hours.

The half-life after oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intense elimination is observed in the first 4 hours after administration.

When taking Mexidol tablets, you should remember the following special instructions:

• When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, an increase in their effects should be expected. The toxic effect of ethanol, when used together, is reduced.
• When taking Mexidol, you should be careful when driving a car or performing potentially dangerous work that requires quick reaction and attention.

It is better not to prescribe Mexidol to patients with arterial hypertension or a critical course of hypertension. For this category of people, the drug is prescribed only after normalization of blood pressure and sedation.

Mexidol is used with caution in persons whose work involves driving vehicles or complex mechanisms and requires increased concentration and attention.

Overdose of the drug is rare. Treatment is symptomatic, aimed at its rapid removal from the body.

Dialysis detoxification methods are used for treatment; it is recommended to drink more fluids.

The medicine reduces the toxic effect and side effects of ethyl alcohol on the body, and also long-term potentiates the effect of benzodiazepine anxiolytics and antiparkinsonian drugs.

The cost of the drug depends on the pharmacy network and dosage. On average, a package (tablets, 30 pcs) can be purchased from 290 to 350 rubles. Large packages (tablets, 50 pcs) can be purchased a little more expensive - 400-450 rubles. The injection form of the drug (ampoules of a 5% solution, 2 ml, 10 pcs) will cost 490-550 rubles, ampoules (20 pcs, 5 ml each) will cost around 1,500 rubles.

Mexidol is a highly effective drug with a very wide range of pharmacodynamic effects on the body. The side effects of the drug are minimal.

Due to its high efficiency (which its analogs do not have), the drug can be used to treat acute and chronic cerebral circulatory disorders. Injection forms of release (ampoules) allow you to start therapy immediately (if indicated).

When is medication prescribed in tablets? Most often, after infusion therapy, patients are transferred to taking medication in tablet form (for the purpose of maintenance therapy, as well as as prophylaxis), when adverse factors affect the body, after which their side effects are reduced.

It fights spasms well and improves brain activity.

Exists in the form of tablets and solutions in ampoules. It has a wide spectrum of action, with few side effects.

special instructions

Mexidol - contraindications

Coronary heart disease is one of the indications for the use of Mexidol

• , but in combination with the interaction of other drugs.
• Negative changes in the blood circulation of the head during the acute stages of the disease.
• For atherosclerosis of brain capillaries (dyscirculatory type encephalopathy).
• Anxiety in neurotic diseases.
• Traumatic brain injury and its consequences.
• Acute cardiac phase (use from the first moments of the situation).
• Cognitive disorders of atherosclerotic etiology of mild form.
• Intoxication with antipsychotic drugs.

In addition to the main indications for use of the drug, it is recommended to use it for the treatment of symptom complexes. The latter is provoked as a result of the negative impact on the nervous system of stressful situations and severe anxiety.

Before purchasing a medication, you need to find out not only what it is for, but also in what cases this medicine cannot be used, namely:

• Intolerance to the composition of the medication;
• Liver failure;
• Malfunction of the kidneys.

It is forbidden to use Mexidol during pregnancy and breastfeeding. This phenomenon is attributed to the fact that there is no accurate data on the effect of the drug on the child.

Why is Mexidol prescribed? The drug is indicated for the treatment of:

1. Vegetative-vascular dystonia;
2. Alcohol and drug addiction;
3. Discirculatory encephalopathy;
4. Pathologies of the brain of an atherosclerotic nature;
5. Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
6. Exposure to extreme (stress) factors;
7. Conditions after acute intoxication with antipsychotic drugs;
8. Anxiety disorders in neurotic and neurosis-like conditions;
9. Mild traumatic brain injury, consequences of traumatic brain injury;
10. Acute pathologies of cerebral circulation.

1. Hypersensitivity to the drug;
2. Acute liver failure;

The instructions for use of the drug Mexidol state that there are many more indications for use than contraindications.

Contraindications

The number of contraindications is much smaller:

• the person’s sensitivity to the drug is too strong;
• a sharp change in kidney performance for the worse;
• a sharp change in liver performance for the worse;
• contraindicated for children.

In cases of impaired functional activity of the kidneys and liver, the use of the drug is prohibited.

This synthetic antioxidant is suitable for internal use. It is produced as a liquid solution for injection and in the form of pills. If the doctor has prescribed Mexidol, the indications for use should be discussed in advance, cases of overdose and contraindications should be excluded. In case of drug incompatibility, it is worth choosing a more gentle analogue with a mild effect on the site of pathology.

The active substance of the chemical formula is ethylmethylhydroxypyridine succinate. The synthetic component improves tissue respiration, which is especially important for all types of hypoxia. In addition, it provides high-quality nutrition to tissues and effectively fights the products of intoxication in the body. The therapeutic effect is almost instantaneous, especially if these are intramuscular injections for shock conditions.

Considering the fact of drug interactions, it becomes obvious that not all patients can use this medication. If you are interested in Mexidol, the first step is to study the contraindications. The manufacturer reports that taking tablets and injections is not recommended if the clinical picture includes:

• renal failure;
• liver problems;
• hypersensitivity to synthetic components.

The Russian-made medicine has a unique two-level effect, so it will not be possible to briefly describe what Mexidol helps with. It affects blood vessels and the condition of nerve cells, producing the following effects:

• antioxidant;
• membrane-protective;
• antihypoxic;
• anticonvulsant;
• nootropic;
• hypolipidemic;
• anxiolytic.

These properties provide an extensive list of disorders for which medicine is needed. Why Mexidol is prescribed in a particular case is determined by the doctor - different problems cannot be solved in the same way, in each regimen the drug performs its own function. For this reason, self-medication is prohibited - it can cause harm even if the recommended doses are followed. The main reasons for prescribing medication are:

• and their consequences;
• vegetative dystonia;
• asthenic reaction;
• the result of an acute lack of cerebral blood supply;
• cognitive impairment of atherosclerotic nature;
• withdrawal syndrome;
• strong stress factors;
• ischemia;
• inflammation of the peritoneal organs;
• poisoning with psychotropic drugs;
• prevention of somatic disorders under high loads.

Due to its relative safety, the list of problems for which the use of such treatment is prohibited is surprisingly small. It includes:

• acute disorders of renal and hepatic functions;
• allergies and intolerance to any component.

Whether Mexidol can be taken by children, pregnant and nursing mothers is decided on a case-by-case basis. There have been no studies on this topic, so doctors avoid using the drug in these groups of people. In rare cases, the appointment may take place, but only if there is confidence that the risk of negative consequences is significantly lower than the expected benefit.

In case of arterial hypertension and crisis, use is carried out under strict control of the pressure level; the use of additional agents is not excluded. Also, caution should be observed when taking it if it is necessary to drive a car and perform complex, high-precision work that requires high concentration of attention. If negative reactions occur, the dosage is revised or the drug is completely discontinued.

Mexidol tablets are used very widely in neurological practice, in particular for the following conditions:

• • ACVA (hemorrhagic and stroke), as well as their consequences.
  • TBI().
  • Abstinence.
  • Poisoning with antipsychotics.
  • Asthenia.
  • within the framework of asthenia.
  • Dizziness of various origins (with vascular diseases of the brain).

There are a number of contraindications to the use of the drug:

• Acute renal failure.
• Allergic reactions to the drug.
• Pediatric practice.
• Pregnancy and lactation.

It is also undesirable to use Mexidol for significant liver dysfunction.

A doctor can prescribe Mexidol therapy only after a complete examination of the patient, diagnosis and testing. The drug has a wide spectrum of action and is prescribed in the following cases:

• After ischemic attacks in the body.
• If there is a circulatory disorder in the patient's brain.
• As a prevention of ischemic stroke.
• After head and skull injuries.
• With vegetative dystonia syndrome.
• At the time of nervous disorders, with feelings of anxiety.
• To combat withdrawal symptoms in alcoholism.
• Prescribed after severe intoxication in the body.
• When the nervous system is damaged by severe stress.
• After strong psychological stress.
• At the time of myocardial infarction.
• With a purulent process in the abdominal area.
• At the time of glaucoma of different stages.

1. If the patient has kidney problems, liver failure.
2. In case of hypersensitivity to the composition of the drug. The patient may be allergic to one of the components of Mexidol. In this case, you need to stop therapy with this drug.
3. Prohibited for children under 16 years of age.
4. Should not be taken by pregnant women.
5. Dangerous for the baby during breastfeeding. The substances of the drug can reach the child through milk and seriously harm his health.

If you have an individual intolerance to the product, you should immediately inform your doctor. He can prescribe analogues of Mexidol, which will help with the disease and will not cause harm to the body.

As a rule, Mexidol must be taken in the presence of the following conditions and diseases:

1. Various results of cerebral accidents (impaired microcirculation of the brain with damage to its tissue as a result of difficulty or complete cancellation of blood flow to its parts).
2. Head injury.
3. Diseases that are associated with vascular damage.
4. Weakness.
5. Ischemia (local decrease in blood supply, in most cases caused by a vascular factor, which leads to temporary dysfunction or damage to a tissue or organ).
6. Neurological diseases (a disease that develops as a result of damage to the brain and spinal cord, as well as peripheral nerve trunks and ganglia).
7. Lethargy.
8. General malaise.
9. Chronic stress (a serious illness that has even more negative consequences: various mental disorders and serious illnesses of internal organs).
10. Withdrawal syndrome in alcoholism (a consequence of depletion of resources of the whole organism in general and the liver in particular).
11. Vegetative-vascular dystonia (a complex of functional disorders based on a violation of the regulation of vascular tone by the autonomic nervous system).

In each situation, a specialist, taking into account all the characteristics of the patient’s body, develops a course of therapy that can achieve the fastest effect. In addition, the doctor will recommend how and at what time it is best to take Mexidol tablets.

Despite the huge range of actions, Mexidol cannot be used by all people. There are situations in which the use of the medicine will not bring the desired effect, for example:

1. Individual intolerance to substances.
2. “Interesting position” of a woman.
3. Breast-feeding.
4. Acute liver and kidney diseases.

Drug interactions

• Prevention of the oxidative process at the cellular level;
• Improving brain activity, including memory, learning and intelligence;
• Restoration of the cell membrane;
• Improving tissue nutrition in case of lack of oxygen;
• Normalization of cholesterol levels;
• Relieving vasospasm;
• Elimination of anxiety and feelings of fear.

The medicine Mexidol, due to its effect, helps relieve intoxication in severe inflammation of the pancreas (pancreatitis). It can also be used to treat problems with cerebral blood flow and to relieve stroke symptoms. Mexidol is also taken for headaches caused by lack of oxygen, as the drug eliminates this problem.

You can take Mexidol for any type of intoxication of the body. The drug reduces the effects of toxins, especially if the cause is taking antipsychotics and alcohol.

Long-term use of Mexidol for VSD has a good effect on the general well-being of the patient. Anxiety is relieved and brain activity increases.

According to the instructions for use, Mexidol is characterized by a complex pharmacological effect, has antioxidant, adaptogenic, nootropic, membrane stabilizing, cerebroprotective, anxiolytic, vegetotropic, anticonvulsant effects:

• Restores the functions and structure of cell membranes, modulates membrane-bound enzymes, improves the interconnection of brain structures and synoptic transmission;
• Improves immune system function, inhibits platelet aggregation;
• Activates the synthesis of protein and nucleic acids inside cells, accelerates enzymatic reactions of the Krebs cycle and glucose utilization, promotes the synthesis of ATP and its accumulation inside cells;
• Improves cerebral hemodynamics, including microcirculation, has a positive effect on blood fluidity, limits the area of ​​cerebral ischemia and stimulates reparative processes;
• Reduces the level of low-density lipoproteins and cholesterol, promotes regression of atherosclerotic changes in blood vessels;
• Inhibits fat peroxidation, activates the antioxidant system, accelerates mitochondrial energy synthesis, and improves cellular energy metabolism.

From the digestive system: individual adverse reactions of a dyspeptic or dyspeptic nature may occur.

Others:
Allergic reactions are possible.

Mexidol can be combined with all drugs used to treat somatic diseases. When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants. Mexidol reduces the toxic effect of ethyl alcohol.

If a patient has doubts about the use of any drug, it is best to consult a specialist. Doctors say that Mexidol tablets can be taken regardless of the time of eating.

The instructions for use for the drug “Mexidol” do not indicate any interactions of the active substance with food or other drugs, which would lead to a decrease in the pharmacological effect of the former or an increase in its toxic effect on the patient’s body.

Now you know how to take Mexidol. Before or after food, it doesn’t matter. The medicine can be taken at any time, regardless of diet.

“Mexidol” is well tolerated by patients and does not irritate the mucous cavity of the gastrointestinal tract. Nausea may occur extremely rarely, but it is not related to the peculiarities of use.

The only key is compliance with the dosage - the daily concentration of the active substance is 250-500 milligrams, which is equal to three to four tablets per day, which must be divided into two or three doses.

Recently, more and more people have to find out what Mexidol helps with. This is due to the growing number of vascular problems for which the drug is used. In addition, the possibility of its use in sports medicine is being considered.

Unlike other drugs that have a powerful effect, Mexidol causes almost no side effects. If the dosage remains adequate to the problem, the following are possible:

• dry mouth;
• desire to sleep;
• nausea.

The volume of the substance obtained depends on what Mexidol helps in a particular case, so you cannot change it yourself. This is explained not so much by the possibility of getting a negative reaction, but by a decrease in effectiveness, which will complicate treatment. The low toxicity of the drug allows you to exceed the dose for a long time without reducing motor activity, a strong desire to sleep, or deteriorating motor coordination or brain function. Because of this, there is a risk of not noticing problems and adjusting the therapeutic regimen too late, which will lead to the need for its revision.

Before prescribing a medicine, the doctor studies its description, excludes contraindications, side effects, and incompatibility with other pharmacological groups as part of complex treatment. This will help prevent a deterioration in the patient’s general well-being and speed up recovery. After prescribing the drug, keep in mind that Mexidol has the following side effects:

• signs of dyspepsia of varying severity;
• local allergic reactions.

Mexidol, interacting with the body, exhibits properties that are not aimed at fighting free radicals.

It has a wide area of ​​action. This drug is prescribed in cases of poor oxygen supply to tissues, or in cases of disruption of this process.

This drug reduces the body's sensitivity
to oxygen-dependent pathological conditions, helps improve memory, ability to work and concentration, and reduces the harmful effects of alcohol on the body.

Mexidol is a drug that exhibits antioxidant properties.
.

Mexidol tablets and injections, as indicated in the instructions for use, help inhibit free radical processes and lipid peroxidation.

It helps activate the antioxidant enzyme superoxide dismutase.
. It has a positive effect on the physicochemical properties of the biomembrane.

During its effect on the human body, this drug acts as a substance that protects membranes, prevents the occurrence of seizures, increases the body’s resistance to the effects of negative factors and prevents the development of oxygen-dependent pathological conditions.

Improves blood circulation and reduces the ability of platelets to attract each other. It helps reduce cholesterol levels.

Under the influence of this drug, the process of lipid peroxidation slows down, superoxide dismutase activity increases, the viscosity of the membrane decreases and, in turn, its fluidity decreases.

Due to its mechanisms of action, it has a small number of contraindications
and has a low level of toxicity.

Overdose

The doctor is obliged to tell the patient about possible side effects. They may not appear, but you still need to get information about them. Please note that side effects can greatly harm the body. Therefore, if your condition suddenly worsens, you should immediately inform your doctor. Here are the main side effects of Mexidol:

1. Nausea or vomiting.
2. Severe dry mouth, constant feeling of thirst.
3. Allergies on the body.
4. Fatigue, constant sleepiness during the day.
5. Fear, anxiety and depression.
6. Emotional activity.
7. Hyperhidrosis.
8. The patient has frequent headaches.
9. Poor coordination, a person may even fall.
10. High blood pressure.
11. Dizziness.

If side effects appear immediately, the doctor should urgently reduce the dose of the prescribed drug or, as a last resort, stop therapy with this drug.

In ampoules

The second form of release of this medicine is a solution for injection. If regular Mexidol is prescribed in this form, ampoules are also available without a prescription. The release version is more effective, since the component - methylhydroxypyridine - immediately enters the systemic bloodstream, has a therapeutic effect, and gives a stable and long-lasting therapeutic effect. The medicine has antioxidant, nootropic, antihypoxic and anxiolytic properties. Indications for use are:

• insufficient nutrition of brain tissue;
• impaired systemic circulation of the cerebral cortex and not only;
• nervous disorders with panic attacks, anxiety states;
• impaired cognitive function;
• open angle glaucoma.

The medication Mexidol in ampoules according to the instructions is administered into the patient’s body intramuscularly or intravenously. It is important to discuss single doses and course duration with your doctor in advance. A similar summary of Mexidol states that a single dose of medication depends on the nature of the pathological process and the degree of neglect of the diagnosed disease. These may be the following standards:

1. Impaired cerebral circulation - 200-500 mg of medication / 14 days.
2. Traumatic brain injuries – 500 mg / 14 days.
3. Circulatory insufficiency in the cerebral cortex – 100-250 ml / 10 days.

The doctor may prescribe Mexidol injections intravenously or intramuscularly. The dose of the drug is prescribed by a specialist individually based on the patient’s diagnosis and stage of the disease.
Sometimes it is necessary to dilute the product with sodium chloride when injecting, using 200 ml per ampoule.

Standard treatment begins with 100 mg of Mexidol 2-3 times a day. The doctor may increase the dose gradually if no side effects are observed. The maximum dose of the drug is 800 mg. Mexidol can be administered:

1. Jet. The injection must be given slowly, over approximately 7 minutes.
2. Drip. Inject 50 drops in 1 minute.

Medicine and driving, use during pregnancy and lactation, use in pediatrics

For the treatment of pediatric children, the use of Mexidol is permitted only in cases of traumatic brain injuries and in the treatment of purulent neuroinfections. Input and monitoring of the child’s condition should be carried out by the attending physician.

The drug does not help expectant mothers recover quickly, but can only harm the intrauterine development of the fetus and provoke extensive pathologies. Clinical studies of such categories of patients have not been carried out, therefore the drug Mexidol is not prescribed during pregnancy. In addition, the medication is contraindicated during lactation.

The drug does not help expectant mothers recover quickly, but can only harm the intrauterine development of the fetus and provoke extensive pathologies. Clinical studies of such categories of patients have been carried out, therefore the drug Mexidol is not prescribed during pregnancy. In addition, the medication is contraindicated during lactation.

Price

The cost of the drug is affordable to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately within the same price range.

It is important to read the instructions before purchasing. The price on the Internet is cheaper, real and positive recommendations from patients, high effectiveness of the drug. If you buy medicine at a pharmacy, the price depends on the city and region. No prescription required.

People mostly find out how much drugs cost by phone or directly upon coming to the pharmacy. The price of the drug is quite stable and depends only on the form of the medication:

• Pills:
  • 30 pcs. – 370 rub.;
  • 50 pcs. – 225 rub.
• Ampoules:
  • 2 ml 10 pcs. – 425 rub.;
  • 2 ml 50 pcs. – 1975 rubles;
  • 5 ml 5 pcs. – 425 rub.;
  • 5 ml 20 pcs. – 1600 rub.

This is a Russian drug that is used for disorders of cerebral microcirculation. How to take Mexidol? In the morning or evening?

The instructions for use for the medicine do not contain information about the compatibility of the active ingredients of the drug with food. In this connection, Mexidol can be taken regardless of the food included in the daily menu.

In addition, among the positive aspects of the drug the following can be identified:

• no nausea after consumption;
• good tolerance;
• antioxidant effect on the body.

Mexidol instructions for use. In this article we will get acquainted with the instructions on how to use the drug Mexidol® - what it helps with, its price and customer recommendations. From the instructions it is known that these are Mexidol tablets, film-coated 125 mg, Mexidol injections (in ampoules) 5% of the drug for the treatment of encephalopathies, TBI and other brain disorders in adults, children and pregnancy.

Excipients:
lactose monohydrate - 97.5 mg, povidone - 25 mg, magnesium stearate - 2.5 mg.

Film shell composition:
opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

• 10 pieces. - contour cellular packaging (1) - cardboard packs;
• 10 pieces. - contour cell packaging (2) - cardboard packs;
• 10 pieces. - contour cellular packaging (3) - cardboard packs;
• 10 pieces. - contour cell packaging (4) - cardboard packs;
• 10 pieces. - contour cell packaging (5) - cardboard packs.

Mexidol® - instructions for use

To optimize the functioning of the body, it is appropriate to take an additional course of prescribed medications. You should choose Mexidol if you need to influence the body’s resources, support the functions and tone of internal systems, especially the central nervous system. Unauthorized use of the drug is strictly contraindicated.

The cost of the drug is affordable to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately within the same price range. It is important to read the instructions before purchasing. The price on the Internet is cheaper, real reviews of high efficiency are positive. If you buy medicine at a pharmacy, the price depends on the city and region. No prescription required.

Mexidol tablets are dispensed from pharmacies with a doctor’s prescription. Found in almost all pharmacies. Average prices vary within wide limits due to various factors and are:

• Pack of 30 tablets 233-290 rubles.
• Pack of 50 tablets 350-475 rubles.

Prices are approximate. An analysis of the drug market for 2019 has not yet been carried out.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

Mexidol is a medicine that stops destructive processes in the body, restores tissues and nourishes them with useful substances. In order not to harm the body during treatment, you need to know exactly how to take such a drug. We will talk about the action of Mexidol, describe its beneficial properties and contraindications.

The medicine contains the active ingredient ethylmethylhydroxypyridine, sodium metabisulfite, povidone, lactose, polyethylene glycol, titanium dioxide.

• Mexidol in tablets of 0.125 g - 50 pieces cost 410-460 rubles.
• Mexidol in tablets of 0.125 g - 30 tablets will cost 270-300 rubles.
• Mexidol in ampoules of 5 ml - 5 pieces cost -450-500 rubles.
• Mexidol in ampoules of 2 ml - 10 ampoules cost 460-510 rubles.

Composition of the drug and scope of application

There are tablet and ampoule versions of this medicine. The doctor chooses which drug Mexidol will be prescribed based on the indications and ease of use. The difference between the different release forms lies in the concentration of the active substance and the presence of auxiliary components. The latter must be paid attention to if there have been cases of intolerance to any pharmaceutical products.

Mexidol - tablets

The main active ingredient is ethylmethylhydroxypyridine succinate, it contains 125 mg, other dosages are not yet produced. The composition of Mexidol tablets includes:

• lactose monohydrate;
• carmellose sodium;
• Magnesium stearate.

The outer part is white or cream in color and consists of:

• talc;
• polyethylene glycol;
• titanium dioxide;
• polyvinyl alcohol.

Mexidol - ampoules

If your doctor has prescribed Mexidol, injections can be an alternative to taking pills. Options are produced with 250 and 100 mg of the main component. Moreover, its concentration in 1 ml is the same in both cases – 50 mg. The ampoules also contain:

• sodium metabisulfide;
• water for injections.

The active ingredient of Mexidol is ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate). An injection solution (50 g/l) or tablets containing 125 mg are available. active substance. This is a domestic drug and is one of the new generation of antioxidant drugs.

As excipients, the Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 liter). Mexidol tablets - excipients are magnesium stearate, sodium carboxymethylcellulose (otherwise known as carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Mexidol - ampoules

Directions for use and doses

Orally, 125 - 250 mg 3 times a day; maximum daily dose - 800 mg (6 tablets). Duration of treatment - 2 - 6 weeks; to relieve alcohol withdrawal - 5 - 7 days. Treatment is stopped gradually, reducing the dose over 2-3 days. Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase until a therapeutic effect is obtained;

The dosage of the drug Mexidol depends on the disease for which it is used

For the treatment of various diseases, there are standard dosages necessary to obtain a positive effect. The following standards are identified for input depending on the disease:

1. acute stage: 5 days - intravenously, by drip at a dose of 100-150 mg, lasting up to 90 minutes. The next 9 days - intramuscularly. The substance should be administered 3 times a day with an interval of 8 hours, while the daily dose for therapy should be calculated from the norm of 6-9 mg per 1 kg of patient weight, but not more than 250 mg at a time.
2. Encephalopathy: 2 weeks of intravenous injection of 250-500 mg, 1-2 times per 24 hours. Afterwards, the dosage is reduced to 100-250 mg per day for the next 14 days.
3. Acute changes in blood circulation in the brain: Administration by drip into the cubital vein in a dose of up to 500 mg 3-4 times, for 1.5-2 weeks. Over the next 2 weeks, the dosage should be reduced by half.
4. Anxiety disorders and mild cognitive dysfunctions: intramuscularly for 2-4 weeks, 150-300 mg per day.
5. Traumatic brain injury and its consequences: drip injection into a vein on the elbow two to four times a day, at a dose of 250-500 mg.
6. Intoxication with anti-psychotic drugs: up to two weeks, the norm is 200 to 500 mg intravenously.

The dose of the drug, which is recommended for use during the day, is calculated individually in each case. It all depends on the patient’s age, the nature and stage of development of the disease. On average, a patient is recommended to take a dose of medication per day.

It is known that taking many medications on an empty stomach has a negative effect on the stomach and digestive system as a whole. To avoid this problem, Mexidol tablets should be taken after meals.

Mexidol tablets are taken orally, regardless of meals. Doses are 1-2 tablets (125-250 mg) three times a day. Maximum dosage 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

For alcohol withdrawal and antipsychotic poisoning, the course of treatment can be 7-10 days.

It is important to use Mexidol correctly for each disease:

• For skull injuries, you need to take Mexidol injections for 2 weeks. You will have to administer 300 mg of the drug 3-4 times a day.
• If you need to improve blood circulation in the brain, use the drug for 10 days. Administer 300 mg once daily as a drop. Then you can administer the drug intramuscularly three times a day, 100 mg.
• In case of myocardial infarction, it is recommended to administer Mexidol intramuscularly for 14 days. In this case, it is necessary to use complex treatment.
• Glaucoma requires treatment for at least 14 days. Administer 200 mg of Mexidol intramuscularly 2 times a day.
• At the time of alcohol withdrawal syndrome, the drug must be administered intravenously 2 times a day. The course of treatment is 7 days.
• In case of severe intoxication by other means, Mexidol should be administered intravenously at 100-200 mg. The course of treatment lasts at least 10 days.
• For pancreatitis, 400 mg of the drug is required 2 times a day. It is advisable to gradually reduce the dose until recovery.

Taking too many pills or injecting too much can cause complications. Most often, a person begins to feel very drowsy.
However, other side effects from the drug may become more serious and cause great harm to your health.

For impaired renal function

The prescription drug is contraindicated in acute renal failure.

Upon completion of the main stage of therapeutic treatment, the patient may be prescribed oral administration of the drug for prophylactic purposes. To find out how to drink Mexidol, you need to consult your doctor.

And other not so widespread medications. Despite the fact that the medicine is not cheap, in order to avoid unwanted side effects, it is not recommended to independently replace it with analogue drugs that have similar therapeutic characteristics.

Uncontrolled oral intake of Mexidol can provoke the following undesirable sensations: heartburn, nausea, headache, belching, general physical weakness, upset stomach. In extremely rare cases, Mexidol can provoke a decrease in blood pressure, impaired motor coordination and emotional hyperreactivity.

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In case of circulatory disorders in the brain, an intravenous course of the drug is prescribed, which is administered for 10-14 days 2-4 times a day, in a volume not exceeding 500 mg, by drip method. After which, for 2 weeks the medicine is administered by intramuscular injection, 2-3 times a day, 200-250 mg of the drug.

Relieving alcohol withdrawal

Mexidol instructions for use is an original drug that has a nootropic effect, so it is often used to eliminate withdrawal symptoms and symptoms of ethyl alcohol poisoning. Many people believe that if the drug is taken simultaneously with alcohol, the effect of the latter can be easily neutralized. But this is just an erroneous assumption.

As the substance penetrates the body, the process of stopping the existing pathology begins, while no protection is provided for the cells. Therefore, to the question of whether they can be used together, there is only one answer: it cannot, since there is no compatibility between the substances.

Disobedience in this regard can cause serious negative consequences in the form of nausea, vomiting, pain and dizziness. However, it is possible to use this drug as a single component in the phased elimination of alcohol dependence. Typically, this technique helps to increase the effectiveness of therapy and instantly eliminate disorders.

Thus, the drug is effective in eliminating numerous ailments and pathological phenomena, and therefore will allow you to recover from any form of many diseases in just a short course. But before using the medicine, it is recommended to consult a specialist.

To relieve alcohol withdrawal syndrome, it is better to take Mexidol tablets for 7 days, as a continuation of treatment, after a course of intramuscular injections. The doctor independently, based on the individual characteristics of the patient’s body, selects the dosage of the drug for the patient and prescribes a regimen for taking the pills.

Mexidol is an antioxidant drug that realizes its effects through the inhibition of free radical processes. It also has membrane protective properties and can have nootropic, mild anticonvulsant, vasoactive and anxiolytic effects.

The drug can increase resistance to damaging influences (hypoxia, ischemia, shock, cerebral circulatory disorders, intoxication with alcoholic beverages or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. The activity of membrane enzymes and receptor complexes is also modulated, which improves the functioning of brain cell membranes. Taking Mexidol improves the functioning of synapses, enhances the mechanism of compensatory glycolysis and reduces the inhibition of oxidative processes in the Krebs cycle under conditions of low oxygen content in cells.

Mexidol is able to reduce platelet aggregation, thereby improving the rheological properties of blood. Stabilizes blood cell membranes during hemolytic processes. Has a mild lipid-lowering effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and dystrophic disorders in brain structures. It has a good antitoxic effect during alcohol abuse, including during abstinence. Reduces the manifestations of acute alcohol intoxication, normalizes behavior, and relieves cognitive impairment due to chronic alcohol consumption. Mexidol can enhance the effect of tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants, which, when taken together, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetically, Mexidol tablets are well absorbed when taken orally. It is quickly distributed throughout organs and tissues, the average duration of action of Mexidol is about 4-5 hours. Metabolized in the liver into 5 metabolites, pharmacologically active metabolites are determined in the urine for up to 48 hours.

The half-life after oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intense elimination is observed in the first 4 hours after administration.

Indications

Mexidol tablets are used very widely in neurological practice, in particular for the following conditions:

• • ACVA (hemorrhagic and stroke), as well as their consequences.
  • TBI().
  • Abstinence.
  • Poisoning with antipsychotics.
  • Asthenia.
  • within the framework of asthenia.
  • Dizziness of various origins (with vascular diseases of the brain).

Contraindications

There are a number of contraindications to the use of the drug:

• Allergic reactions to the drug.
• Pediatric practice.
• Pregnancy and lactation.

It is also undesirable to use Mexidol for significant liver dysfunction.

Mode of application

Mexidol tablets are taken orally, regardless of meals. Doses are 1-2 tablets (125-250 mg) three times a day. Maximum dosage 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

For alcohol withdrawal and antipsychotic poisoning, the course of treatment can be 7-10 days.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible with Mexidol.

Overdose

Mexidol tablets are safe to use; cases of overdose are extremely rare. In case of overdose, general weakness or drowsiness may develop.

special instructions

When taking Mexidol tablets, you should remember the following special instructions:

• When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, an increase in their effects should be expected. The toxic effect of ethanol, when used together, is reduced.
• When taking Mexidol, you should be careful when driving a car or performing potentially dangerous work that requires quick reaction and attention.

Storage conditions

Mexidol tablets should be stored in a dark, dry place at temperatures no higher than 24-25 degrees Celsius. The storage period should not exceed 3 years.

Analogs

Mexidol tablets are an original medicine. Generic drugs, the active ingredient of which is alsoate, are drugs such as Mexifin, Mexicor, Metostabil, as well as some other drugs that are not widely used on the market.

Video commentary by the author

Price

Mexidol tablets are dispensed from pharmacies with a doctor’s prescription. Found in almost all pharmacies. Average prices vary within wide limits due to various factors and are:

• Pack of 30 tablets 233-290 rubles.
• Pack of 50 tablets 350-475 rubles.

Prices are approximate. An analysis of the drug market for 2019 has not yet been carried out.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

This is a Russian drug that is used for disorders of cerebral microcirculation. How to take Mexidol? In the morning or evening?

The instructions for use for the medicine do not contain information about the compatibility of the active ingredients of the drug with food. In this connection, Mexidol can be taken regardless of the food included in the daily menu.

In addition, among the positive aspects of the drug the following can be identified:

• no nausea after consumption;
• good tolerance;
• antioxidant effect on the body.

Indications

As a rule, Mexidol must be taken in the presence of the following conditions and diseases:

1. Various results of cerebral accidents (impaired microcirculation of the brain with damage to its tissue as a result of difficulty or complete cancellation of blood flow to its parts).
2. Head injury.
3. Diseases that are associated with vascular damage.
4. Weakness.
5. Ischemia (local decrease in blood supply, in most cases caused by a vascular factor, which leads to temporary dysfunction or damage to a tissue or organ).
6. Neurological diseases (a disease that develops as a result of damage to the brain and spinal cord, as well as peripheral nerve trunks and ganglia).
7. Lethargy.
8. General malaise.
9. Chronic stress (a serious illness that has even more negative consequences: various mental disorders and serious illnesses of internal organs).
10. Withdrawal syndrome in alcoholism (a consequence of depletion of resources of the whole organism in general and the liver in particular).
11. Vegetative-vascular dystonia (a complex of functional disorders based on a violation of the regulation of vascular tone by the autonomic nervous system).

In each situation, a specialist, taking into account all the characteristics of the patient’s body, develops a course of therapy that can achieve the fastest effect. In addition, the doctor will recommend how and at what time it is best to take Mexidol tablets.

Should I take the drug before or after meals? Read more about this.

Contraindications

Despite the huge range of actions, Mexidol cannot be used by all people. There are situations in which the use of the medicine will not bring the desired effect, for example:

1. Individual intolerance to substances.
2. "Interesting position" of a woman.
3. Breast-feeding.
4. Acute liver and kidney diseases.

Peculiarities

How to take Mexidol, before or after meals? Food does not affect the absorption of the drug in any way. The drug is an antioxidant drug; as a rule, it is used for disorders of the functioning of the brain.

If you read the instructions for use of Mexidol in more detail, it indicates only the dosages that can be taken per day, as well as the duration of therapy with this medication.

So how should you take Mexidol, before or after meals? The use of the drug is not tied to food intake, that is, a person can take it when it is convenient for him. The basic rule is compliance with the dosage and sequence of administration.

Interaction

If a patient has doubts about the use of any drug, it is best to consult a specialist. Doctors say that Mexidol tablets can be taken regardless of the time of eating.

The instructions for use of the drug "Mexidol" do not indicate any interactions of the active substance with food or other medications, which would lead to a decrease in the pharmacological effect of the former or an increase in its toxic effect on the patient's body.

Now you know how to take Mexidol. Before or after food, it doesn’t matter. The medicine can be taken at any time, regardless of diet.

"Mexidol" is well tolerated by patients and does not irritate the mucous cavity of the gastrointestinal tract. Nausea may occur extremely rarely, but it is not related to the peculiarities of use.

The only key is compliance with the dosage - the daily concentration of the active substance is 250-500 milligrams, which is equal to three to four tablets per day, which must be divided into two or three doses.

How to take Mexidol before or after meals is a question that worries patients in the first place. In order to avoid side effects, you must follow the instructions for use.

Abstract to the medicine

The instructions for the drug do not contain information about the compatibility of the active ingredients of the drug with food products. In this regard, Mexidol can be taken regardless of the food included in the daily menu. In addition, among the advantages of the drug, the following characteristics can be distinguished:

• no nausea after administration;
• well tolerated by patients;
• antioxidant effect on the body.

Indications for use

This medication can be recommended for use by specialists in various medical fields. As a rule, Mexidol should be taken if you have the following health problems:

• various consequences of brain accidents;
• head injuries;
• diseases associated with impaired vascular function;
• ischemia;
• neurological diseases;
• weakness, lethargy and general malaise.

In each case, a specialist, taking into account all the characteristics of the patient’s body, develops a course of treatment with which the most effective effect can be achieved. In addition, the doctor will advise how and at what time to take the tablets correctly - before or after meals.

Contraindications

Despite the wide range of effects, Mexidol cannot be taken by all patients. There are cases in which the use of the medication will not be beneficial and will not help cope with the disease:

• individual intolerance to components;
• pregnancy;
• lactation period;
• acute liver and kidney failure.

Application options and daily dose

The drug is available in 2 forms:

The dose of the drug, which is recommended for use during the day, is calculated individually in each case. It all depends on the patient’s age, the nature and stage of development of the disease. On average, a patient is recommended to take a dose of medication per day.

It is known that taking many medications on an empty stomach has a negative effect on the stomach and digestive system as a whole. To avoid this problem, Mexidol tablets should be taken after meals.

Similar drugs

There are a sufficient number of drugs whose composition is similar to Mexidol. Among its main substitutes are:

The drugs are produced in tablets or ampoules intended for injection.

In addition to the similarity in composition, there are medications that resemble Mexidol in the nature of their effect on the body:

How to take Mexidol tablets

The popular new generation drug Mexidol, which belongs to the group of new generation antioxidants, is designed to stop destructive processes in the human body. Therefore, you need to know how to take Mexidol tablets to restore and normalize metabolic processes in brain cells, so as not to harm the body.

Composition of the drug and scope of application

The active ingredient in Mexidol is ethylmethylhydroxypyridine succinate 125 mg, resulting in the following type of effect on the body:

• Hypoxia tolerance improves;
• Mental abilities and concentration improve;
• The body can more easily tolerate stressful situations of various types;
• The state of nervousness is relieved;
• The toxic effects of alcohol on the body are reduced;
• Blood circulation in the brain improves;
• Sleep, appetite and general condition of the body improves.

Mexidol tablets, according to the instructions attached to the drug, are indicated for use to prevent cell oxidation and stabilize the structure of intracellular membranes. Regular use of this drug prevents platelet aggregation, reduces cholesterol levels in the blood and prevents the development of degenerative processes, thereby slowing down the aging process of the body.

Release form

Mexidol is available on the pharmaceutical market in 2 dosage forms: tablets and ampoules.

For oral administration, the tablet form of this drug is used, biconvex in shape, in a white or cream-colored shell. Which are packaged in 10 pieces, in cell blisters.

To administer Mexidol intramuscularly or by infusion, the medicine is released in ampoules made of white or darkened glass. The solution, contained in an ampoule of 2–5 ml, is a colorless or slightly yellow liquid, odorless and contains 50 mg of ethylmethylhydroxypyridine succinate per 1 ml of solution. The drug is injected intramuscularly into the upper outer quadrant of the gluteal muscle.

Mexidol is stored in a dry, dark place, indoors with a maximum temperature increase of up to 25 ° C. If unpacked, Mexidol is stored for up to 3 years from the date of production indicated on the package.

Taking Mexidol and its dosage

Mexidol tablets should be taken one or two tablets 3 times a day, taking into account the individual tolerance of the drug, but without exceeding the maximum dose of 600 mg, most often the course of treatment with Mexidol takes into account taking the medication for 14 - 42 days. With a gradual exit from it, which involves a daily reduction in the daily dose of the drug.

Use of Mexidol for VSD

For vegetative-vascular dystonia, the drug is taken in tablets at a dose of 125–250 mg, up to 3 times a day, or according to a regimen drawn up by the attending physician, which takes into account the individual characteristics of the patient and allows to minimize side effects from the use of the drug.

If after taking the medicine the patient feels lethargic or persistent drowsiness, it is necessary to contact the attending physician to review the dosage of the medicine. To avoid negative consequences for the body, it is not recommended to stop taking the pills on your own.

After taking Mexilod, during the treatment of VSD, the patient experiences a significant improvement in the psychological state, aggressiveness disappears, the feeling of depression and oppression goes away, and recovery from a depressive state is accelerated.

Relieving alcohol withdrawal

To relieve alcohol withdrawal syndrome, it is better to take Mexidol tablets for 7 days, as a continuation of treatment, after a course of intramuscular injections. The doctor independently, based on the individual characteristics of the patient’s body, selects the dosage of the drug for the patient and prescribes a regimen for taking the pills. The medicine entering the patient’s body quickly relieves withdrawal symptoms, restores the psycho-emotional background, improves memory and promotes rapid cleansing of the body when ingesting ethanol.

Cerebral circulatory disorders

In case of circulatory disorders in the brain, an intravenous course of the drug is prescribed, which is administered for 10-14 days 2-4 times a day, in a volume not exceeding 500 mg, by drip method. After which, for 2 weeks the medicine is administered by intramuscular injection, 2-3 times a day, 200-250 mg of the drug.

Upon completion of the main stage of therapeutic treatment, the patient may be prescribed oral administration of the drug for prophylactic purposes. To find out how to drink Mexidol, you need to consult your doctor.

Medicines with a similar spectrum of action

Mexidol is an original medicinal product with a patented active ingredient; its analogues on the pharmaceutical market are:

And other not so widespread medications. Despite the fact that the medicine is not cheap, in order to avoid unwanted side effects, it is not recommended to independently replace it with analogue drugs that have similar therapeutic characteristics.

Side effect of Mexidol, with uncontrolled use

Uncontrolled oral intake of Mexidol can provoke the following undesirable sensations: heartburn, nausea, headache, belching, general physical weakness, upset stomach. In extremely rare cases, Mexidol can provoke a decrease in blood pressure, impaired motor coordination and emotional hyperreactivity.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

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Mexidol ® tablets

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

INSTRUCTIONS for medical use of the drug Mexidol ®

Registration number: LSR/07 dated 08/09/2007

Trade name of the drug: Mexidol

Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form: film-coated tablets

Active substance: ethylmethylhydroxypyridine succinate mg, excipients: lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description: Tablets are round, biconvex, film-coated, from white to white with a creamy tint.

Pharmacotherapeutic group: antioxidant agent.

Pharmacological properties:

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)). The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes. The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins. The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol has a pronounced antitoxic effect in withdrawal symptoms. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Rapidly absorbed when taken orally. The maximum concentration at mg doses is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in urine immediately after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates. Tx/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications for use:

Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);

Autonomic dystonia syndrome;

Mild cognitive disorders of atherosclerotic origin;

Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;

Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;

Impact of extreme (stress) factors.

Contraindications:

Acute liver and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Directions for use and dosage:

Orally, mg 3 times a day; maximum daily dose of zamg (6 tablets). Duration of treatment: week; for relief of alcohol withdrawal days. Treatment is stopped gradually, reducing the dose over the course of days. The initial dose is 50 mg (1 - 2 tablets) once a day with a gradual increase until a therapeutic effect is obtained. Maximum daily dose of mg (6 tablets).

Side effect:

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Interaction with other drugs:

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

Special instructions:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose:

Release form: Film-coated tablets, 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each along with instructions for use per pack. For hospital use Film-coated tablets 125 mg. 450 and 900 tablets in a plastic jar made of food grade plastic along with instructions for use in corrugated cardboard boxes.

Storage conditions: List B. Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 3 years. Do not use after the expiration date indicated on the pack.

Dispensing conditions: By prescription

A: ZiO-Zdorovye CJSC, Moscow region, Podolsk, st. Zheleznodorozhnaya 2

B: CJSC ALSI-Pharma, CJSC ALSI Pharma, Moscow, Trifonovsky deadlock, 3,

Organization receiving claims: LLC NPK Pharmasoft, Moscow, st. Avtozavodskaya, 22

Pharmgroup:

Therapeutic effect:

Reviews and comments

My baby is 8 months old

Anna Fri, 02/08/:49

My child is 8 months old, diagnosed with PPCNSL. The neurologist prescribed Mexidol 1/4 tablet 2 times a day, but the instructions say that Mexidol is contraindicated for children, since no studies have been conducted. Can a child have Mexidol or not?

The doctor may prescribe for the child

A doctor may prescribe a drug to a child if the expected benefit is greater than the risk. Follow the neurologist's prescription. The experience of using Mexidol in children in previous studies showed positive results in the treatment of childhood neurological diseases.

Take Mexidol tablets

Guest Fri, 02/08/:50

Should Mexidol tablets be taken before or after meals, is this not written in the instructions?

Taking Mexidol tablets is not

Taking Mexidol tablets does not depend on food intake.

Hello, I have VSD, and

Inna Fri, 02/08/:01

Hello, I have VSD and acute panic attacks, can I take Mexidol?

Mexidol has been successfully used

Mexidol is successfully used to treat manifestations of vegetative-vascular dystonia, including elements of panic attacks.

For a month I took

Tatyana Fri, 02/08/:16

For a month I took Mexidol tablets, 1 tablet. 3 times a day, after the course I found out that I was pregnant. I am very worried about whether taking this drug will affect the baby and the course of pregnancy.

Don't worry, it won't hurt.

Don't worry, it won't hurt. Mexidol is an antioxidant and contains succinate, which is functionally significant for many processes occurring in the body, in particular, being a substrate for increasing energy metabolism in cells.

My child is 2 years and 9 months old.

Svetlana Fri, 12/12/:18

My child is 2 years and 9 months old. The neurologist prescribed Mexidol, Valfen and Magne B6 for us to take for a month, mix all three drugs 1/3+ 1/3 +3 ml twice a day. This is due to the fact that the child cried in kindergarten, did not eat anything and could not get used to the kindergarten.

Please tell me this will not harm the child.

Such drugs are not

Such drugs are not prescribed simply because a child cries in kindergarten. An accurate diagnosis is needed.

And the child also rose

Svetlana Sat, 13/12/:00

And the child also started vomiting from anxiety, while crying, while eating. For 2 weeks.

After the doctor prescribed these drugs (Mexidol, Valfen and Magne B6), he ordered a fundus test - the result was normal, plus he didn’t prescribe anything else.

Please tell me what to do?

At this time we are not visiting the kindergarten, and everything is fine at home with the child.

If the child is healthy, there is no need

If the child is healthy, there is no need to stuff him with medications.

tell me which one it should be

Vladimir Thu, 02/04/:49

Tell me what the taste of Mexidol should be, I drank one package of tablets, they had no taste, I took another one, it tasted sour

The taste depends on the shell, in

The taste depends on the shell; normally it should not be there.

Likewise! My parents

Natalya Wed, 08/02/:47

Likewise! My parents took Mexidol for many years, but the last time the pills tasted salty! I asked the manufacturer a question and they wrote back that taste doesn’t matter. But still there are vague doubts, what if it’s a fake? How to find out. There are already 4 boxes lying around.

Hello! I was prescribed

Lara Sat, 11/07/:26

Hello! I was prescribed Mexidol, when I went to the pharmacy I read that it contains lactose, and I am allergic to it. To make an appointment with a doctor is a long wait. Tell me what can replace Mexidol.

Medomexi solution for

Medomexi solution for intravenous and intramuscular administration is a lactose-free analogue. Also look at the active ingredient: ethylmethylhydroxypyridine succinate, the list of analogues is at the end of the instructions, and in general, you can ask the pharmacist at the pharmacy about such a replacement

I took Mexidol in

Tatyana Fri, 25/09/:23

I took Mexidol from April to May for 1 month, is it possible to use it after 5.5 months if there are indications for this?

The drug must be prescribed by a doctor

The drug must be prescribed by a doctor during a face-to-face appointment, and he also prescribes the duration of treatment.

Good afternoon. I have

Olga Sat, 26/09/:02

Good afternoon. I'm 19 weeks pregnant and have severe headaches. The neurologist prescribed me Mexidol 1 tablet 3 times, take it for a month. The instructions say it is contraindicated to take during pregnancy. What effects can Mexidol have on a child?

The effect of the drug on the fetus is not

The effect of the drug on the fetus has not been studied, so pregnancy is listed as a contraindication. It's better to be safe than sorry.

My son has low platelets

Irina Sun, 22/11/:04

My son has low platelets, can we take Mexidol?

This is not

This is not a contraindication. Contraindication: children's age.

Application of Maximov for

Valentina. Fri, 05/02/:16

Is there a place to use Maksimov for left-sided facial motor tics?

Can Mexidol in injections

Olga Sat, 06/02/:53

Can Mexidol injections cause a miscarriage if the pregnancy was short?

The effect of the drug on

The effect of the drug during pregnancy has not been studied.

Good afternoon, tell me

Svetlana Tue, 09/02/:05

Good afternoon, please tell me whether it is possible to take Mexidol and gliatilin at the same time. A neurologist prescribed these medications to us; we are one year old. If not, please tell me what is better, thank you.

Can

These drugs do not interact with each other. For children only as prescribed by a doctor, after weighing the risks and expected benefits.

take before or after meals

Guest Tue, 15/03/:53

take before or after meals

Already answered the same question above

Guest Tue, 15/03/:11

The doctor has already answered the same question above.

If you miss a pill

Mark Thu, 04/07/:37

If you miss a Mexidol tablet, should you skip it or take a double one?

Take the next one as soon as

Take the next one as soon as you remember. No need to double.

Hello. The child is 11 months old.

Kukenova Dina Tue, 07/06/:03

Hello. The child is 11 months old. Diagnosis of perinatal CNS damage of hypoxic-ischemic origin, mild severity, late recovery period. The neuropathologist prescribed Mexidol 1/4 tablet 2 times a day. 2 months. Is it dangerous to drink it for so long?

Use of the drug in

The use of the drug in childhood has not been sufficiently studied. The doctor prescribes the dosage and timing, weighing the risks and benefits.

Child 6 years old, a year ago

Irina Thu, 30/06/:00

The child is 6 years old, stuttering began a year ago. A pediatric psychoneurologist prescribed magnesium B6 - 1 tablet per day, Mexidol - 0.5 tablets, glycine - 1 t. twice a day. It helped a year ago. Now there is practically no effect. Maybe I need to increase the dose?

Is it possible to take Mexidol?

Natalya Tue, 06/09/:14

Is it possible to take Mexidol at the same time as glycine?

The interaction of these

No interaction of these drugs has been noted.

I took a pill at 9am

Galina Thu, 15/09/:02

At 9 am I took a Betaserc tablet. I was prescribed Mexidol tablets. Is it possible to take Mexidol on the same day at 17:00? Please tell me.

there were no pills in the pharmacy -

flura Wed, 02/11/:54

There were no tablets at the pharmacy, so I bought them in ampoules - can I just drink them?

Sveta Fri, 18/11/:11

I took a course of one tablet per day, does it have an effect or must it be taken as written in the instructions. How often can I take Mexidol? Is it addictive?

There shouldn't be any habituation.

There shouldn't be any habituation. Take as prescribed by your doctor.

I want to say a huge thank you

Margarita Fri, 31/03/:09

I would like to say a huge thank you to the neurologist who prescribed me Mexidol. I’ll be honest, I really don’t trust all the pills, I read a lot of reviews, some praise, some don’t seem to feel anything, you don’t know whether to drink or not to drink, but my emotional health has already reached a critical point, chronic neurosis has already finished me off, Panic attacks also tormented me, I thought that I was almost in pre-stroke conditions, I lost my speech for half a minute, what strange reasoning, which I can’t remember later, in general, it’s not life, but hell. I bought the pills and started drinking. on the first day I drank 1 tablet in the morning and 1 tablet. in the evening, on the first day, I didn’t even understand such a quick result, my head became clear, the desire to live returned, I can’t even express all my emotions, we’ll see how it goes, I’ve only been drinking for 2 days, thanks again to the doctor, who, one might say, got me back on my feet , but I still don’t understand that such progress happened in one day, although the reviews write that Mexidol has a cumulative effect. That's how it happens.

Mexidol and Mexicor are one thing

Nadezhda Wed, 05/24/:00

Are Mexidol and Mexicor the same thing?

The active ingredient is the same

The active ingredient is the same.

Tell me, should I take it?

Ruslan Tue, 30/05/:18

Tell me, you need to take it exactly 3 times a day, i.e. every 8 hours, or maybe in the morning, afternoon, and evening? Thank you.

Any drug is desirable

It is advisable to take any drug at the most equal intervals of time, for example at 7, 15 and 23

Thanks good prepor

Ivan Mon, 14/08/:44

Thank you, good drug.

My son (15 years old) was prescribed

Nadezhda Thu, 12/10/:06

My son (15 years old) was prescribed Mexidol, 1 tablet twice a day. My son has VSD and astheno-neurotic syndrome. According to the instructions, you need to do it three times. How to use?

When receiving, always

When taking the drug, they are always guided by the doctor’s prescription, since the dosage is selected taking into account not only the diagnosis, but the characteristics of the patient - age, weight, test results, etc.

Mexidol analogue, which

Olga Thu, 12/10/:45

Please name an analogue of Mexidol that is cheaper!

Mexidol instructions for use. In this article we will get acquainted with the instructions on how to use the drug Mexidol® - what it helps with, its price and customer recommendations. From the instructions it is known that these are Mexidol tablets, film-coated 125 mg, Mexidol injections (in ampoules) 5% of the drug for the treatment of encephalopathies, TBI and other brain disorders in adults, children and pregnancy.

Excipients: lactose monohydrate - 97.5 mg, povidone - 25 mg, magnesium stearate - 2.5 mg.

Film shell composition: opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

• 10 pieces. - contour cellular packaging (1) - cardboard packs;
• 10 pieces. - contour cell packaging (2) - cardboard packs;
• 10 pieces. - contour cellular packaging (3) - cardboard packs;
• 10 pieces. - contour cell packaging (4) - cardboard packs;
• 10 pieces. - contour cell packaging (5) - cardboard packs.

Mexidol® - instructions for use

To optimize the functioning of the body, it is appropriate to take an additional course of prescribed medications. You should choose Mexidol if you need to influence the body’s resources, support the functions and tone of internal systems, especially the central nervous system. Unauthorized use of the drug is strictly contraindicated.

Compound

The active ingredient of Mexidol is ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate). An injection solution (50 g/l) or tablets containing 125 mg are available. active substance. This is a domestic drug and is one of the new generation of antioxidant drugs.

As excipients, the Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 liter). Mexidol tablets - excipients are magnesium stearate, sodium carboxymethylcellulose (otherwise known as carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Mexidol tablets instructions for use

Mexidol tablets are intended for oral administration. The daily dose varies from 375 to 750 mg, the frequency of doses is 3 (one or two tablets three times a day). The maximum permissible dose is 800 mg. per day, which corresponds to 6 tablets.

The duration of treatment depends on the disease and the patient’s body’s response to the prescribed treatment. As a rule, it ranges from two weeks to one and a half months. In cases where the drug is prescribed to relieve symptoms of alcohol withdrawal, the duration of the course is from five to seven days.

In this case, abrupt discontinuation of the drug is unacceptable: treatment is stopped gradually, reducing the dose over two to three days. At the beginning of the course, the patient is prescribed to take one or two tablets per dose, once or twice a day. The dose is gradually increased until a positive clinical effect is obtained (it should not exceed 6 tablets per day).

The duration of the therapeutic course in patients diagnosed with ischemic disease is from one and a half to two months. If necessary, a second course may be prescribed as prescribed by a doctor. The optimal time to prescribe a repeat course is autumn and spring.

What is Mexidol prescribed for - indications for use

Why is Mexidol prescribed? The drug is indicated for the treatment of:

1. Vegetative-vascular dystonia;
2. Alcohol and drug addiction;
3. Discirculatory encephalopathy;
4. Pathologies of the brain of an atherosclerotic nature;
5. Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
6. Exposure to extreme (stress) factors;
7. Conditions after acute intoxication with antipsychotic drugs;
8. Anxiety disorders in neurotic and neurosis-like conditions;
9. Mild traumatic brain injury, consequences of traumatic brain injury;
10. Acute pathologies of cerebral circulation.

What is Mexidol taken for and what does it help with? Mexidol is indicated for the relief of: “Withdrawal syndrome” and various conditions that occur during oxygen deprivation.

Price for Mexidol

The cost of the drug is affordable to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately within the same price range.

It is important to read the instructions before purchasing. The price on the Internet is cheaper, real and positive recommendations from patients, high effectiveness of the drug. If you buy medicine at a pharmacy, the price depends on the city and region. No prescription required.

Directions for use and doses

Orally, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets).
Duration of treatment - 2 - 6 weeks; to relieve alcohol withdrawal - 5 - 7 days. Treatment is stopped gradually, reducing the dose over 2-3 days. Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets). The duration of therapy in patients with coronary heart disease is at least 1.5 - 2 months. Repeated courses (on the recommendation of a doctor) are preferably carried out in the spring and autumn periods.

pharmachologic effect

According to the instructions for use, Mexidol is characterized by a complex pharmacological effect, has antioxidant, adaptogenic, nootropic, membrane stabilizing, cerebroprotective, anxiolytic, vegetotropic, anticonvulsant effects:

• Restores the functions and structure of cell membranes, modulates membrane-bound enzymes, improves the interconnection of brain structures and synoptic transmission;
• Improves immune system function, inhibits platelet aggregation;
• Activates the synthesis of protein and nucleic acids inside cells, accelerates enzymatic reactions of the Krebs cycle and glucose utilization, promotes the synthesis of ATP and its accumulation inside cells;
• Improves cerebral hemodynamics, including microcirculation, has a positive effect on blood fluidity, limits the area of ​​cerebral ischemia and stimulates reparative processes;
• Reduces the level of low-density lipoproteins and cholesterol, promotes regression of atherosclerotic changes in blood vessels;
• Inhibits fat peroxidation, activates the antioxidant system, accelerates mitochondrial energy synthesis, and improves cellular energy metabolism.

Contraindications

1. Hypersensitivity to the drug;
2. Acute liver failure;
3. Acute renal failure.

Mexidol is not prescribed to children due to insufficient knowledge of the drug's effect.

Side effects

From the digestive system: individual adverse reactions of a dyspeptic or dyspeptic nature may occur.

Others: Allergic reactions are possible.

Overdose

In case of overdose, drowsiness may develop.

Drug interactions

Mexidol can be combined with all drugs used to treat somatic diseases. When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants. Mexidol reduces the toxic effect of ethyl alcohol.

special instructions

Influence on the ability to drive vehicles and operate machinery. During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

For impaired renal function

The prescription drug is contraindicated in acute renal failure.

Mexidol injections instructions for use

The second form of release of this medicine is a solution for injection. If regular Mexidol is prescribed in this form, ampoules (injections) are also available without a prescription.

The release version is more effective, since the component - methylhydroxypyridine - immediately enters the systemic bloodstream, has a therapeutic effect, and gives a stable and long-lasting therapeutic effect. The medicine has antioxidant, nootropic, antihypoxic and anxiolytic properties. What does Mexidol help with? Indications for use are:

• Impaired cognitive function;
• Disturbed systemic circulation of the cerebral cortex and not only;
• Nervous disorders with panic attacks, anxiety;
• Open angle glaucoma;
• Insufficient nutrition of brain tissue.

The medication Mexidol injections according to the instructions is injected into the patient’s body into the muscle or intravenously. It is important to discuss single doses and course duration with your doctor in advance.

A similar summary of Mexidol instructions for use states that a single dose of medication depends on the nature of the pathological process, the degree of neglect of the diagnosed disease. These may be the following standards:

1. Traumatic brain injuries – 500 mg / 14 days;
2. Circulatory insufficiency in the cerebral cortex – 100-250 ml / 10 days;
3. Impaired cerebral circulation - 200-500 mg of medication / 14 days.
4. In the presence of mild cognitive impairment, older people inject about 300 mg/day into the muscle for up to thirty days;
5. Acute diseases of a purulent-inflammatory nature - from the first days of treatment and after the end of the operation. The required dosage is calculated by a specialist; the duration of use of the drug will depend on the form and severity of the disease. Features and characteristic features of its course. Mexidol is discontinued gradually, as soon as a stable clinical effect is achieved and blood counts stabilize;
6. For mild necrotizing pancreatitis - up to 200 mg three times a day. Choose one of the administration methods or use a combination of them;
7. For necrotizing pancreatitis, if it is severe, 800 mg is prescribed on the first day in a pulse dosage. For the following days, 200 to 500 mg is prescribed twice a day;
8. Encephalopathy (injections can only be done during the decompensation phase) - 200-400 mg of Mexidol intravenously twice a day for fourteen days. Over the next two weeks, about 200 mg are administered. 1 per day. A preventive measure occurs by administering a 250 mg solution intramuscularly. twice a day for two weeks;
9. In case of acute poisoning with neuroleptics, 300-500 mg/day is prescribed for a week;
10. For acute pancreatitis, accompanied by swelling, up to 500 mg of the drug Mexidol is prescribed 3 times a day by drip or injection into the muscle;
11. For alcohol withdrawal, 250 mg/daily is prescribed intravenously by drip or three injections into the muscle for one week.

The exact dosage of Mexidol should be selected by a doctor. Mexidol can be administered intravenously by drip. Another method of administration is jet. It is administered directly into a vein using a syringe.

There is no need to dilute this solution. The rate of administration of the ampoule is no more than seven minutes. If Mexidol is injected into a muscle, then it must be given in the center of the upper quadrant of the buttock.

Mexidol during pregnancy

The drug does not help expectant mothers recover quickly, but can only harm the intrauterine development of the fetus and provoke extensive pathologies. Clinical studies of such categories of patients have not been carried out, therefore the drug Mexidol is not prescribed during pregnancy. In addition, the medication is contraindicated during lactation.

Mexidol is contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug's effect.

Mexidol and alcohol compatibility

Mexidol instructions for use is an original drug that has a nootropic effect, so it is often used to eliminate withdrawal symptoms and symptoms of ethyl alcohol poisoning. Many people believe that if the drug is taken simultaneously with alcohol, the effect of the latter can be easily neutralized. But this is just an erroneous assumption.

As the substance penetrates the body, the process of stopping the existing pathology begins, while no protection is provided for the cells. Therefore, to the question of whether they can be used together, there is only one answer: it cannot, since there is no compatibility between the substances.

Disobedience in this regard can cause serious negative consequences in the form of nausea, vomiting, pain and dizziness. However, it is possible to use this drug as a single component in the phased elimination of alcohol dependence. Typically, this technique helps to increase the effectiveness of therapy and instantly eliminate disorders.

Thus, the drug is effective in eliminating numerous ailments and pathological phenomena, and therefore will allow you to recover from any form of many diseases in just a short course. But before using the medicine, it is recommended to consult a specialist.

Mexidol - analogues

If these injections give an allergic reaction, adjustment of the treatment regimen is necessary. Drugs similar in composition to Mexidol also act productively; the main thing is to choose the safest medication for a particular clinical picture. According to doctors' recommendations, Cerecard, Mexiprim, Mexidant, Neurox, Mexicor have proven themselves well.

Actovegin and Mexidol: The drugs have similar uses and are often prescribed together. Actovegin is produced on the basis of an extract from calf blood, so allergic reactions are more likely to develop to it. Improves nutrition and tissue regeneration. Unlike Mexidol, Actovegin is used for disorders in peripheral vessels, and to treat the consequences of such disorders - trophic ulcers and angiopathy.

What's better than Mexidol? Since the drug has recently appeared on the market, its research is ongoing. In the case of a particular patient, those remedies that give the maximum effect are always good. If there is no improvement within two to three days of using Mexidol, it is better to replace it with other drugs. There is no clear answer to the question of which drugs are better. The selection of a treatment regimen is individual and depends on the level of qualifications of the attending physician.

Mexidol or Mexiprim? Mexiprim is a German drug, similar in its properties to the domestic Mexidol. Produced by the Stada Arzneimittel concern. It differs only in the excipients included in the shell and core of the tablets.

Mexidol or Cavinton? The active ingredient of Cavinton is a semi-synthetic derivative of vincamine (devincan) contained in periwinkle - vinpocetine. It is a vasodilator used to improve blood circulation in the brain. Slightly reduces blood pressure, improves the supply of glucose and oxygen to the brain.

It is also used in ophthalmology and the treatment of age-related diseases of the ENT organs. Both drugs complement each other and are often used together in the treatment of cerebrovascular problems. It is not advisable to mix these drugs in one dropper; it is better to administer them separately.

Mexidol or Mildronate? Mildronate (trimethylhydrazinium propionate) is a vasodilator, improves oxygen supply to tissues, increases humoral and tissue immunity, lowers blood pressure, and is used in the treatment of coronary artery disease. It can be prescribed together with Mexidol for withdrawal symptoms and disorders of the blood supply to the brain, since the drugs complement each other.

Mexidol or Neurox? These two drugs are identical and contain the same active ingredient.

Mexidol or Cortexin? Cortexin contains an extract from bovine brain polypeptides. The choice of drug depends on the individual reaction of the patient’s body to it. Together, both drugs are used in the treatment of acute brain hypoxia in newborns. Prescribed only by the attending physician.

Mexidol or Nootropil? The active ingredient of Nootropil is piracetam. The drugs are often prescribed together to treat memory impairment, the consequences of ischemic stroke, alcoholism, and improving learning ability in children.

Mexidol is a medicine that stops destructive processes in the body, restores tissues and nourishes them with useful substances. In order not to harm the body during treatment, you need to know exactly how to take such a drug. We will talk about the action of Mexidol, describe its beneficial properties and contraindications.

The medicine contains the active ingredient ethylmethylhydroxypyridine, sodium metabisulfite, povidone, lactose, polyethylene glycol, titanium dioxide.

Description of the drug

Mexidol increases the body's resistance to various injuries, protects against shock, ischemia and nervous disorders. It is an anticonvulsant and nootropic agent. The drug increases dopamine content in the brain, improves blood circulation and microcirculation. Has an effective anti-stress effect.

Release form of the drug Mexidol

The medicine can be purchased in the form of tablets and ampoules for injection. They produce packs of tablets of 50 or 30 pieces. The medicine is covered with a white shell. The drugs should be stored at a temperature of no more than 25 degrees in a dark place. The standard shelf life of the medicine is 3 years.

Indications for use of Mexidol

A doctor can prescribe Mexidol therapy only after a complete examination of the patient, diagnosis and testing. The drug has a wide spectrum of action and is prescribed in the following cases:

• After ischemic attacks in the body.
• If there is a circulatory disorder in the patient's brain.
• As a prevention of ischemic stroke.
• After head and skull injuries.
• With vegetative dystonia syndrome.
• At the time of nervous disorders, with feelings of anxiety.
• To combat withdrawal symptoms in alcoholism.
• Prescribed after severe intoxication in the body.
• When the nervous system is damaged by severe stress.
• After strong psychological stress.
• At the time of myocardial infarction.
• With a purulent process in the abdominal area.
• At the time of glaucoma of different stages.

Contraindications to taking the medicine

The doctor must warn the patient when Mexidol is prohibited from taking. If you neglect these recommendations, you can significantly harm your health. So, the drug is prohibited in the following cases:

1. If the patient has kidney problems, liver failure.
2. In case of hypersensitivity to the composition of the drug. The patient may be allergic to one of the components of Mexidol. In this case, you need to stop therapy with this drug.
3. Prohibited for children under 16 years of age.
4. Should not be taken by pregnant women.
5. Dangerous for the baby during breastfeeding. The substances of the drug can reach the child through milk and seriously harm his health.

If you have an individual intolerance to the product, you should immediately inform your doctor. He can prescribe analogues of Mexidol, which will help with the disease and will not cause harm to the body.

Side effects from Mexidol

The doctor is obliged to tell the patient about possible side effects. They may not appear, but you still need to get information about them. Please note that side effects can greatly harm the body. Therefore, if your condition suddenly worsens, you should immediately inform your doctor. Here are the main side effects of Mexidol:

1. Nausea or vomiting.
2. Severe dry mouth, constant feeling of thirst.
3. Allergies on the body.
4. Fatigue, constant sleepiness during the day.
5. Fear, anxiety and depression.
6. Emotional activity.
7. Hyperhidrosis.
8. The patient has frequent headaches.
9. Poor coordination, a person may even fall.
10. High blood pressure.
11. Dizziness.

If side effects appear immediately, the doctor should urgently reduce the dose of the prescribed drug or, as a last resort, stop therapy with this drug.

How to use Mexidol tablets?

Doctors usually prescribe the drug in 250 mg tablets no more than 3 times a day. Mexidol tablets should be taken orally and washed down with plenty of water. The maximum dose per day is 800 mg. This is approximately 6 tablets. It is not recommended to exceed this limit without a doctor's prescription.

The usual course of treatment with Mexidol lasts about 4 weeks. To stop alcohol withdrawal, it is enough to take the drug for a week.

The course of treatment for cardiac ischemia usually lasts 2 months. The doctor may prescribe a repeat course of Mexidol. It is best to re-do it in the spring or autumn.

Method of using Mexidol in ampoules

The doctor may prescribe Mexidol injections intravenously or intramuscularly. The dose of the drug is prescribed by a specialist individually based on the patient’s diagnosis and stage of the disease. Sometimes it is necessary to dilute the product with sodium chloride when injecting, using 200 ml per ampoule.

Standard treatment begins with 100 mg of Mexidol 2-3 times a day. The doctor may increase the dose gradually if no side effects are observed. The maximum dose of the drug is 800 mg. Mexidol can be administered:

1. Jet. The injection must be given slowly, over approximately 7 minutes.
2. Drip. Inject 50 drops in 1 minute.

Basic doses for diseases

It is important to use Mexidol correctly for each disease:

• For skull injuries, you need to take Mexidol injections for 2 weeks. You will have to administer 300 mg of the drug 3-4 times a day.
• If you need to improve blood circulation in the brain, use the drug for 10 days. Administer 300 mg once daily as a drop. Then you can administer the drug intramuscularly three times a day, 100 mg.
• In case of myocardial infarction, it is recommended to administer Mexidol intramuscularly for 14 days. In this case, it is necessary to use complex treatment.
• Glaucoma requires treatment for at least 14 days. Administer 200 mg of Mexidol intramuscularly 2 times a day.
• At the time of alcohol withdrawal syndrome, the drug must be administered intravenously 2 times a day. The course of treatment is 7 days.
• In case of severe intoxication by other means, Mexidol should be administered intravenously at 100-200 mg. The course of treatment lasts at least 10 days.
• For pancreatitis, 400 mg of the drug is required 2 times a day. It is advisable to gradually reduce the dose until recovery.

Taking too many pills or injecting too much can cause complications. Most often, a person begins to feel very drowsy. However, other side effects from the drug may become more serious and cause great harm to your health.

Medicine and driving

Doctors do not recommend getting behind the wheel or driving a car while being treated with Mexidol. The medicine slows down a person's natural reactions and reduces concentration. This may lead to an accident and other dangerous consequences. It is also not recommended to engage in other activities that may require a lot of concentration from a person.

Interaction of tablets with other drugs

Mexidol combines well with other drugs and does not weaken their effect. The product will reduce the effect and toxicity of ethyl alcohol. The drug will enhance the effect of antidepressants and anticonvulsants.

Prices for Mexidol drugs

You can buy Miksidol tablets and ampoules at any pharmacy without a doctor's prescription. Prices vary everywhere, but the average cost of a medicine can be noted:

• Mexidol in tablets of 0.125 g - 50 pieces cost 410-460 rubles.
• Mexidol in tablets of 0.125 g - 30 tablets will cost 270-300 rubles.
• Mexidol in ampoules of 5 ml - 5 pieces cost -450-500 rubles.
• Mexidol in ampoules of 2 ml - 10 ampoules cost 460-510 rubles.

Mexidol analogues

The doctor may prescribe another drug, which in properties and active ingredients will be similar to Mexidol. Now there are such analogues of this tool:

• Antifront.
• Armandine.
• Glycine.
• Glycised.
• Glutamic acid.
• Instenon.
• Keltican.
• Mexiprim.
• Memory plus.
• Rilutek.
• Tenoten.
• Tryptophan.
• Cytoflavin.

Mexidol reviews

Since the drug has a wide spectrum of action, you can find many patient reviews about it. To learn about the real effect of Mexidol, we recommend reading some of them:

• Yana, 37 years old. The doctor prescribed me to take Mexidol for osteochondrosis in order to improve my nervous condition. During my illness, I often experienced bouts of depression and fear, especially in its advanced stages. There was no desire to start treatment or go to procedures. After the first week of taking Mexidol, my condition immediately improved, my mood lifted, and motivation appeared. I had more strength and I stopped being afraid of sudden back pain. At the same time, I began to comprehensively treat osteochondrosis, do gymnastics and undergo physical procedures.
• Anton, 29 years old. I started taking Mexidol to quickly cope with attacks during vegetative-vascular dystonia. This disease causes a sharp feeling of fear, chest pain, panic and shortness of breath. It feels like you are dying. The doctor advised me to take Mexidol for a month. I took 1 tablet a day and immediately noticed improvements. At night I began to sleep well, I was no longer tormented by insomnia and fear. I took the drug for a month and even forgot about my attacks. I stopped worrying and took up my favorite hobbies.

• Irina, 41 years old. The doctor prescribed Mexidol to me along with complex treatment for cervical osteochondrosis. At that moment I had vertebral artery syndrome, which was accompanied by severe pain and impaired blood flow to the brain. Because of this, I suffered from headaches, depression, irritability and even dizziness. I was given regular injections of Mexidol in ampoules. The drug improved my blood circulation, I began to sleep easily again and stopped being nervous. After a long course of Mexidol, the pain subsided, vision improved, and the overall activity of the body increased. I immediately began to work productively, and there was no unpleasant fatigue. Side effects did not bother me even after long injections.

Conclusion

Now you know how Mexidol works in the form of tablets and ampoules. We have described for which diseases such a drug is suitable and how to use it correctly for effective recovery. You have become familiar with a number of side effects and contraindications to the medicine. Mexidol really improves blood circulation, stops destructive processes in the body, and calms the patient’s nervous system. But for such results, you need to take Mexidol exactly as prescribed by the doctor, do not exceed the dosage and inform the doctor about any changes in the body.

All these conditions are successfully relieved by the drug Mexidol. The question of when to inject Mexidol in the morning or evening worries many

Brief description of the drug

Mexidol is prescribed by a neurologist or cardiologist for the treatment of diseases of the brain, heart and nervous system. It helps perfectly both with mild vegetative-vascular disorders and with serious pathologies:

• asthenic syndrome due to alcohol dependence;
• acute cerebrovascular accident;
• coronary heart disease;
• stroke and heart attack;
• severe intoxication with neuroleptics;
• neurosis-like and psychosomatic disorders;
• oxygen starvation of tissues of various etiologies (hypoxia).

It is actively used during the recovery period after traumatic brain injuries and purulent inflammation of the abdominal organs. Approved for use by almost everyone except children (under 12 years old) and pregnant women. It is well tolerated, with the rare exception of individual intolerance to the components.

Mexidol is produced in tablets and injections, which allows it to be used in different ways - orally, intramuscularly, intravenously. In this case, it can be administered in a stream or drip, depending on the severity of the condition. Doctors are inclined to believe that it is better to inject Mexidol for a more systemic and faster effect.

When is the best time to inject Mexidol?

The injection form of the drug is available in the form of a concentrated solution in ampoules. 1 ml of medicine contains 50 mg of the active substance (ethylmethylhydroxypyridine succinate). There are no universal instructions for use. In each individual clinical case, an individual treatment regimen and course duration are selected:

• for mild autonomic disorders, an injection of Mexidol is given intramuscularly at a dosage of mg per day for 2-4 weeks;
• severe conditions associated with dysfunction of cerebral circulation require drip or jet administration of the drug in an amount of mg 2-4 times a day

Most experts agree that Mexidol should be injected in the morning, that is, in the first half of the day. There is good reason for this recommendation. The drug has a tonic effect, it invigorates and activates the cardiovascular system. If you take the injection before bed, it will be difficult to fall asleep. Therefore, for a one-time use, it is advisable to give the injection in the morning. If the treatment regimen involves dividing it into several doses, then the evening procedure should be carried out several hours before bedtime.

Mexidol is used exclusively as prescribed by a doctor, so the nuances of the timing of the injection are discussed individually.

Mexidol tablets: instructions for use

Mexidol is an antioxidant drug that realizes its effects through the inhibition of free radical processes. It also has membrane protective properties and can have nootropic, mild anticonvulsant, vasoactive and anxiolytic effects.

Available in the form of biconvex round tablets of white or cream color. The active ingredient of Mexidol tablets isate, content 125 mg in 1 tablet. The substance was first synthesized in the 1980s at the State Research Institute of Pharmacology of the Russian Academy of Medical Sciences. Included in many standards for the provision of medical care in the Russian Federation. In addition to the active substance, the tablets contain excipients: macrogol, polyvinyl alcohol, talc and titanium compounds. It is also available in injections for intramuscular or intravenous injections.

The drug can increase resistance to damaging influences (hypoxia, ischemia, shock, cerebral circulatory disorders, intoxication with alcoholic beverages or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. The activity of membrane enzymes and receptor complexes is also modulated, which improves the functioning of brain cell membranes. Taking Mexidol improves the functioning of synapses, enhances the mechanism of compensatory glycolysis and reduces the inhibition of oxidative processes in the Krebs cycle under conditions of low oxygen content in cells.

Mexidol is able to reduce platelet aggregation, thereby improving the rheological properties of blood. Stabilizes blood cell membranes during hemolytic processes. Has a mild lipid-lowering effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and dystrophic disorders in brain structures. It has a good antitoxic effect during alcohol abuse, including during abstinence. Reduces the manifestations of acute alcohol intoxication, normalizes behavior, and relieves cognitive impairment due to chronic alcohol consumption. Mexidol can enhance the effect of tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants, which, when taken together, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetically, Mexidol tablets are well absorbed when taken orally. It is quickly distributed throughout organs and tissues, the average duration of action of Mexidol is about 4-5 hours. Metabolized in the liver into 5 metabolites, pharmacologically active metabolites are determined in the urine for up to 48 hours.

The half-life after oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intense elimination is observed in the first 4 hours after administration.

Indications

Mexidol tablets are used very widely in neurological practice, in particular for the following conditions:

• ACVA (hemorrhagic and ischemic stroke), as well as their consequences.
• TBI (concussion).
• Encephalopathy.
• Encephalopathy of combined origin.
• Anxiety disorders.
• Abstinence.
• Poisoning with antipsychotics.
• Asthenia.
• Weakness and dizziness as part of asthenia.
• Dizziness of various origins (with vascular diseases of the brain).

Contraindications

There are a number of contraindications to the use of the drug:

• Allergic reactions to the drug.
• Pediatric practice.
• Pregnancy and lactation.

It is also undesirable to use Mexidol for significant liver dysfunction.

Mode of application

Mexidol tablets are taken orally, regardless of meals. Doses are 1-2 tablets (mg) three times daily. Maximum dosage 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

For alcohol withdrawal and antipsychotic poisoning, the course of treatment can be 7-10 days.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible with Mexidol.

Mexidol tablets are safe to use; cases of overdose are extremely rare. In case of overdose, general weakness or drowsiness may develop.

special instructions

When taking Mexidol tablets, you should remember the following special instructions:

• When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, an increase in their effects should be expected. The toxic effect of ethanol, when used together, is reduced.
• When taking Mexidol, you should be careful when driving a car or performing potentially dangerous work that requires quick reaction and attention.

Storage conditions

Mexidol tablets should be stored in a dark, dry place at temperatures not higher than degrees Celsius. The storage period should not exceed 3 years.

Analogs

Mexidol tablets are an original medicine. Generic drugs, the active ingredient of which is alsoate, are such drugs as Neurox, Mexifin, Mexiprim, Armadin, Mexidant, Mexicor, Cerecard, Metostabil, as well as some other drugs that are not widely used on the market.

Mexidol tablets are dispensed from pharmacies with a doctor’s prescription. Found in almost all pharmacies. Average prices vary within wide limits due to various factors and are:

• Pack of 30 tablets rubles.
• Pack of 50 tablets rubles.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

Video commentary by the author

Mexidol tablets and injections: instructions for use, analogues

Mexidol is a popular drug that was developed in 1996 by Russian scientists. Refers to a new generation of antioxidants, used to improve cerebral circulation. It is part of a group of nootropic drugs, the action of which is aimed at normalizing metabolic processes in brain cells and protecting them from free radicals. This allows Mexidol to be widely used in neurological practice.

Its use is not limited to one area of ​​medicine; the drug is used to treat various pathologies in psychiatry, surgery and narcology. The unique properties of the antioxidant allow not only to restore memory, speech and skills lost as a result of a stroke or ischemic brain damage, but also increase the body's resistance to various intoxications and stressful situations. In addition, Mexidol, as part of complex therapy, helps to stop acute purulent-inflammatory processes in the abdominal cavity. Let us dwell in more detail on the therapeutic effect of this drug, methods of its use and tell you what it helps with.

Mexidol - the effect of the drug

Mexidol is an antioxidant agent with nootropic, antihypoxic, anticonvulsant and antistress effects. The main active ingredient is ethylmethylhydroxypyridine succinate. The main objective of the drug is to increase the body's resistance to the action of various damaging factors (hypoxia, cerebrovascular accident, ischemia, intoxication).

Mexidol helps improve blood microcirculation, better blood supply to the brain and restore metabolism in nerve cells. Under its action, the structure of cell membranes is stabilized, platelet aggregation is reduced, and cholesterol levels in the blood are reduced.

The nootropic effect of the drug is expressed in the activation of mental activity, increasing the ability to learn and assimilate information, and improving memory. As an antioxidant, the drug protects body cells from excessive oxidation, reduces the harmful effects of free radicals, slows down aging and increases the resistance of organs and tissues to oxygen starvation.

The use of Mexidol helps restore the disrupted sleep-wake cycle and reduce the rate of development of degenerative processes. When using the drug, the production of the “hormone of joy” - dopamine - increases, which makes Mexidol an excellent remedy for the treatment of depressive conditions.

This hormone helps relieve anxiety, suppresses anxiety and fear, and helps with sleep disorders, neurological and autonomic disorders. The drug has anti-stress, anticonvulsant and antihypoxic effects, promoting oxygen saturation in the blood.

The drug helps to weaken the toxic effect of alcohol, relieves acute withdrawal syndrome, restores behavioral disorders, and has an anticonvulsant effect. The combined use of Mexidol with tranquilizers, antidepressants, sleeping pills, and antipsychotics enhances their effect, which makes it possible to reduce the doses of these drugs and reduce adverse reactions.

When taken orally, Mexidol is quickly absorbed and distributed in organs and tissues. The drug is excreted from the body in the urine in the form of metabolites; a small amount of the drug is excreted unchanged. The greatest intensity of excretion is observed within 4 hours after taking a dose of the drug.

Composition and release form

Photo: Medicine Mexidol in the form of oral tablets

Mexidol is produced in two dosage forms:

• Medicine Mexidol in the form of oral tablets
• Mexidol in ampoules for IV and intramuscular administration

Mexidol tablets are biconvex, coated with a white or slightly cream color. In a cross section, two layers are visible: a gray core and a white outer shell. One tablet contains 125 mg of active ingredient. The drug is packaged in contour cell blisters of 10 tablets each (3-5 blisters per package) or plastic jars containing 90 tablets. For hospitals, the drug is sold in plastic containers containing 450 or 900 tablets.

The drug solution is produced in ampoules made of colorless or dark glass, with a white break point, which are packaged in 5 or 10 pieces in contour cellular blisters. One or two blisters are placed in a cardboard package with the drug. Mexidol ampoules have a volume of 2 and 5 ml. This form of the drug is a clear, colorless or slightly yellowish solution intended for infusion or intramuscular injection. 1 ml of solution contains 50 mg of active substance.

Mexidol is stored in a dry place, protected from light. Storage temperature should not exceed 25°C; all forms of the drug are suitable for use for 3 years.

When is Mexidol prescribed - indications

In medical practice, the list of diseases for which Mexidol is used is quite extensive. It is primarily used in neurology to treat the following conditions:

• Prevention and treatment of strokes in the acute and recovery period
• Manifestations of vegetative-vascular dystonia
• Progressive cerebrovascular insufficiency (encephalopathy)
• Mild traumatic brain injury and its consequences
• Cognitive disorders resulting from atherosclerosis (impaired intelligence, memory, speech)
• Ischemic disease
• Asthenic syndrome

• Prevention of somatic neuroses
• Neurotic disorders: anxiety, sleep disorders
• For symptoms of antipsychotic poisoning
• Under extreme stress factors

• Relieving withdrawal symptoms
• Relieving alcohol withdrawal, manifested in vegetative-vascular and neurotic symptoms

• As part of complex therapeutic treatment for acute purulent-inflammatory pathologies of the peritoneum (peritonitis, necrotizing pancreatitis).

Experts consider the most appropriate use of Mexidol for sclerosis, encephalopathies of various etiologies, vegetative-vascular dystonia, convulsive conditions, epilepsy, neuroses, phobias and traumatic brain injuries.

Instructions for use (tablets, solution for injections)

Photo: Instructions for use (tablets, solution for injections)

According to the instructions for use of Mexidol, the drug, when taken orally, is prescribed 1-2 tablets three times a day. At the beginning of treatment, the recommended dose is taken once or twice a day, then the frequency of administration is increased to achieve the desired effect. The maximum daily dose should not exceed 800 mg (6 tablets). The duration of treatment is from 2 to 6 weeks; to relieve withdrawal symptoms, it is enough to take the drug for 7 days.

Treatment cannot be abruptly interrupted; the dose should be gradually reduced over 3 days until the drug is completely discontinued. The optimal treatment regimen is selected by the doctor, taking into account the individual characteristics of the patient, general condition and severity of symptoms. For ischemic disease, the course of treatment is longer - up to 8 weeks; if necessary, the doctor can prescribe a second course of therapy after a break. The most optimal period for a second course of treatment is spring and autumn.

Mexidol solution can be administered intravenously and intramuscularly. Before infusion administration using a dropper, the drug should be diluted in an isotonic sodium chloride solution. The rate of drip infusion should not exceed drops per minute. The recommended volume of the drug is ml. The jet injection must be carried out very slowly, over 5-6 minutes.

For the treatment of acute cerebrovascular accidents, the drug should be infused according to a specific scheme. In the first day, the volume of intravenous mg is administered by intravenous drip from 2 to 4 times a day. In the next 2 weeks, intramuscular injections are carried out, administering the drug 2-3 times a day.

To eliminate the consequences of traumatic brain injury, the drug is administered by drip in a volume of 2 to 4 times a day, depending on the patient’s condition. The course of therapy is days.

For slowly progressing circulatory failure, the dose is selected individually by the attending physician. The drug is administered intravenously or by bolus once a day for 2 weeks. Further treatment is carried out using intramuscular injections.

For anxiety disorders and cognitive impairment in elderly people, the drug is administered intramuscularly in a daily dose of 100 to 300 mg. Treatment is carried out for 2-4 weeks.

To eliminate alcohol withdrawal, the medicine is infused intramuscularly or using a dropper. Perform 2-3 procedures per day, administering the drug in a volume of 200 to 500 mg.

For purulent abscesses of the abdominal cavity, Mexidol can be administered intravenously or intramuscularly the day before surgery, or on the first day after surgery. The dose is selected individually, it depends on the severity of the disease, the degree of damage and the general condition of the patient.

Contraindications

Contraindications to the use of the drug are:

• Individual intolerance to the components of the drug
• Pregnancy and breastfeeding period
• Childhood
• Acute dysfunction of the liver and kidneys

Since the effect of the drug has not been sufficiently studied, it is not used to treat children, pregnant and lactating women. Particular caution is taken when using Mexidol in patients with hypertension, low blood pressure, arterial hypertension accompanied by crises.

The instructions for the drug say that it is not prescribed in childhood, but in pediatrics it is still used in the treatment of traumatic brain injuries and purulent neuroinfections. As an emergency aid for injuries, a single use of Mexidol at a dose of 100 mg is indicated. In other cases, the dose of the drug is selected individually by the pediatrician and depends on the child’s condition, the severity of the pathological process and the general clinical picture. The treatment is carried out under the supervision of a specialist.

Side effects from using the drug are minor. Mexidol is characterized by low toxicity and does not have a negative effect on blood composition, respiratory rhythm, or heart rate. In rare cases, adverse reactions from the gastrointestinal tract may occur. After taking the pills, symptoms of a dyspeptic nature are noted, which manifest themselves as discomfort and painful sensations in the abdomen.

Patients complain of nausea, heartburn, a feeling of fullness and heaviness in the abdomen. This condition may be accompanied by the development of diarrhea. In some cases, individual reactions are expressed in appetite disturbance, flatulence, a feeling of weakness, and lethargy. With increased sensitivity to the components of the drug, allergic reactions occur.

When treated with Mexidol solution, patients may experience attacks of nausea, increased dry mouth, weakness and drowsiness. In rare cases, allergic reactions develop.

Taking the drug in high doses can provoke surges in blood pressure, increased emotional excitability, symptoms of hyperhidrosis, and impaired coordination of movements. In case of overdose, gastric lavage and other methods of symptomatic therapy are used.

Drug interactions with other drugs

Mexidol has good compatibility with all drugs used to treat somatic diseases. Simultaneous use with neuroleptics, antidepressants, tranquilizers and anticonvulsants enhances their therapeutic effect, which allows you to reduce the dose of these drugs and avoid the development of unwanted side reactions of the body.

Mexidol reduces the toxic effect of ethanol and promotes the removal of alcohol from the body. This feature of the drug is used to eliminate withdrawal symptoms in the treatment of alcohol addiction.

The use of Mexidol in patients with bronchial asthma suffering from hypersensitivity to sulfites can cause the development of severe allergic reactions.

The drug can slow down the speed of reactions and reduce concentration, so it should be used with extreme caution when driving a vehicle or performing work involving dangerous mechanisms and requiring rapid psychomotor reactions.

Analogs

Mexidol has a number of analogues that are similar in composition and pharmacological action:

Many patients during treatment are interested in whether it is possible to replace Mexidol with cheaper analogues? Despite the fact that the drug is not cheap, it has established itself in the domestic market as the most effective and successful product. Many of its analogues, which have a similar therapeutic effect, differ only in the composition of the excipients and, according to the doctor’s decision, can be used as part of combination therapy together with Mexidol.

But it is not recommended to independently replace the medicine with analogues, since many of them have undesirable side effects or may have insufficient therapeutic effect. The decision to replace should be made by a specialist who will take into account possible contraindications and select the required dosage.

Average prices for the drug in the pharmacy chain:

• Mexidol tablets (30 pieces) – rubles
• Mexidol tablets (50 pieces) – rubles
• Mexidol solution (5 ampoules) – rubles
• Mexidol solution (10 ampoules) – rubles.

Reviews about the application

Vegeto - vascular dystonia is a very unpleasant companion that has been accompanying me for the last few years. It becomes especially unpleasant when the seasons change: incessant headaches, dizziness and drowsiness. I had to seek help from a local clinic. The doctor advised Mexidol intramuscularly.

I read the instructions for use and realized that it suits me. To be honest, I did not expect any stunning effect from the drug. However, Mexidol not only met all my expectations, but also became a savior for me. The injections themselves turned out to be painless, and after ten such procedures I felt like a human being.

A real person who leads an active life and does not constantly suffer from dizziness, migraines and loss of strength. Plus, my concentration has improved, I can now do anything and not fall asleep on the go or lie on the bed suffering from a headache. I did not find any side effects during the treatment. The course of treatment has ended, the therapeutic effect is still lasting. If in the future old problems make themselves felt, now I know what will help me out.

Review #2

I myself have not taken this drug, but I had the opportunity to see it in action with my own eyes. Grandfather had a mini-stroke, his leg was partially paralyzed, he dragged it a lot when walking, speech was difficult. The attending physician prescribed Mexidol as one of the elements of complex treatment. As a result, after taking this drug, my grandfather began to feel better.

Over time, speech returned to normal, memory returned, and you can communicate with him as before. Today, no signs of the attack are visible. Grandfather talks, walks independently, leads a normal lifestyle. Everything returned to normal, and I am sure that Mexidol contributed to this.

My work involves mental activity. I have to spend almost the whole day at the computer. I began to suffer from severe headaches. The attacks were so strong that nausea set in. I went to the clinic. We carried out an examination and the doctor said that the headaches were caused by increased intracranial pressure and deterioration of cerebral circulation.

That is why I started having these attacks. The doctor prescribed Mexidol. I was afraid that the price would be too high, but for such an effective drug it turned out to be quite acceptable. I bought a pack of tablets (50 pieces) and started taking them. Within a week after starting treatment, the headache began to hurt less. And the work became easier, my concentration improved.

True, I felt discomfort in my stomach for some time, and dry mouth appeared, but these phenomena soon passed. After a month of taking the drug, I completely forgot about headaches. I even slept better. Two months have passed since the course of treatment, and so far everything is good: my head doesn’t hurt, I feel much better.

Instructions for use of the drug "Mexidol"

Mexidol comes with instructions for use, which allow you to understand all the properties of the drug, recommendations for use, and contraindications. The medication is sold in pharmacies only with a doctor's prescription, complete with official instructions from the manufacturer.

Composition of the drug and its pharmacological properties

The 1st ampoule of solution contains 50 mg of ethylmethylhydroxypyridine succinite. Auxiliary components: sodium metabisulfite, saline solution, magnesium stearate, sodium carmellose, lactose monohydrate, polyvinyl alcohol, talc, titanium dioxide. "Mexidol" tablets contain 125 mg of active substance.

The drug belongs to the group of nootropics and has a positive effect on all mental processes in the human body. Under the influence of the drug, many pathological changes stop their development. Thanks to the action of the medicine, a person sleeps better.

All this is achieved due to the fact that the active component in the drug is able to restore the functionality of cell membranes and remove free radicals from the body. Taking the drug helps saturate the blood with oxygen, relieves stress, and has anticonvulsant and antioxidant effects. Thanks to improved circulation in the circulatory system, cholesterol levels are reduced and the physiological qualities of plasma are improved (viscosity, flow rate, etc.). In cellular mitochondria, the drug promotes the active formation of energy, and in nerve cells the transmission of synoptic impulses is significantly accelerated.

It is recommended to take Mexidol in combination with tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants. The active substance in the medicine only enhances the effect of the above medications. This combination allows you to reduce the dose, which eliminates many side effects.

Mexidol is widely used in dentistry.

Treatment with Mexidol during pregnancy is not recommended, since there is no reliable data on clinical studies on patients taking this drug during pregnancy.

The drug is often used in complex therapy of children with traumatic brain injuries and purulent neuroinfections. A single dosage is prescribed only by the attending physician. The child is closely monitored while taking the medicine.

In what situations is it used and possible contraindications?

The use of the drug "Mexidol" is indicated for the following diseases:

• vegetative-vascular dystonia;
• disturbances of speech function, intellectual activity, memory and attention;
• vascular diseases in brain tissue;
• withdrawal syndrome that occurs during alcoholism;
• neuroses;
• poisoning with antipsychotic drugs;
• inflammatory processes with purulent formations in the peritoneal organs.

Taking the drug is contraindicated for persons who have an individual intolerance to Mexidol. It is also not recommended to drink Mexidol in case of acute renal and liver failure.

The medicine is practically non-toxic, so the side effects of Mexidol occur very rarely. Regardless of dosage, it does not affect the patient's physical activity level or physiological functions. All reflexes, hemodynamic processes, blood pressure, body temperature remain normal. An overdose may cause nausea and drowsiness. Dry mouth occurs, but quickly goes away on its own. Hypersensitivity to the active substance sometimes causes allergic manifestations in the form of a skin rash.

Due to the drug’s ability to quickly remove toxins and free radicals from the body, it is used to relieve painful symptoms of alcohol intoxication.

Types of drug

"Mexidol" tablets. The initial dosage is 1 – 2 tablets 2 times a day, after which the frequency of administration is increased to 3 times a day. Treatment therapy lasts on average 2–6 weeks, depending on the severity of the disease and the general condition of the patient. The dosage is gradually reduced, approaching the completion of the therapeutic course of treatment. So, people suffering from alcohol addiction drank Mexidol for 7 days.

Rinsing and applying applications. In dental practice, Mexidol injection solutions are successfully used for rinsing the mouth and washing periodontal pockets. Local applications with the solution have a good effect. Procedures must be performed regularly, at least 3 times a day. Treatment takes as long as necessary to achieve positive dynamics in the development of the pathology.

Injection. The 5% solution is produced in ampoules of 2 ml. It can be used for intravenous, intramuscular injections, droppers. Saline solution is used as a solvent.

The dose is strictly individually selected by the attending physician depending on the purpose, disease and severity of its course. Treatment is started with the minimum dose, then increased to the maximum allowable. Up to 0.8 g of the drug can be administered per day.

Treatment of dementia in older patients is carried out using intramuscular injections. The drug, administered intravenously, is good for acute intoxication of the body and inflammatory diseases of the peritoneal organs.

The drug "Mexidol" is well absorbed and quickly eliminated from the body. It undergoes breakdown in the liver within 5 hours after the first dose, then is completely excreted in the urine.

"Mexidol" in dentistry

Due to the property of Mexidol to have an anti-inflammatory and antioxidant effect, it is widely used in dentistry as a therapeutic and prophylactic agent for stomatitis, gingivitis, and caries. It is added to toothpaste, which fights periodontitis, stops bleeding gums, reduces their sensitivity, eliminates pathogenic bacteria, and significantly increases immunity in the oral cavity. After regular use of Mexidol Dent toothpaste, patients note healing of wounds, restoration of the oral mucosa, and the disappearance of unpleasant odor.

It is recommended to brush your teeth with Mexidol Dent 3 times a day or after meals. If gum sensitivity is excessively high, then doctors prescribe Mexidol Dent Sensitive. The paste contains potassium nitrate. This substance allows you to block nerve endings, which reduces the overall sensitivity of teeth that occurs in many diseases. With regular use of the paste, many painful symptoms go away.

Toothpaste has an effective whitening effect and quickly relieves inflammation. Plaque is removed with papain. It contains calcium citrate and hydroxyapatite. These substances penetrate deep into the enamel of the teeth after the plaque from their surface is completely removed. For a long period of time, teeth remain fresh, clean and white.

The effect of Mexidol in the treatment of other diseases

For the drug to be effective, it is necessary to adhere to a strictly defined treatment regimen:

1. If blood circulation in the brain tissue is impaired, the drug is administered via a dropper for 2 weeks. The maximum permissible dose per day is 500 mg. Then they begin to gradually reduce the dosage of the drug, bringing it to 250 mg per day.
2. Encephalopathy in the acute phase. The medicine is administered intravenously 2 times a day for 2 weeks. The dosage ranges from 250 to 500 ml of Mexidol. After this, over the next 2 weeks, reduce the administration of the drug to half the original dosage.
3. Mild disorders of the mental processes of the central nervous system in older patients require treatment with intramuscular injections. The course of therapy ranges from 2 weeks to 30 days. 100–300 ml of the drug is administered. The medication is also used to prevent many mental illnesses.
4. To eliminate alcohol withdrawal syndrome or withdrawal, the doctor prescribes up to 250 mg of Mexidol, administered intravenously or intramuscularly. The duration of treatment is 5 – 6 days.
5. Poisoning with antipsychotics occurs from uncontrolled use of the drug. Painful symptoms are quickly relieved with intravenous injections with a maximum dose of 500 mg.
6. In case of purulent infections of the peritoneum, as well as inflammatory processes of its organs, Mexidol is used from the first hours after surgery. The doctor calculates the dosage of the drug depending on the severity of the disease, form and individual characteristics. As soon as the therapeutic effect is achieved, the drug begins to be gradually withdrawn.
7. Acute pancreatitis, accompanied by edema. A maximum dosage of up to 500 mg per day 3 times a day is allowed. The medication is administered using a dropper or intramuscularly.
8. Moderate purulent pancreatitis. Treat only with a dropper using 200 mg of the drug. The course of treatment lasts from 2 to 4 weeks. Droppers must be placed 3 times a day.
9. Necrotizing pancreatitis. Treatment is prescribed using a large dose (up to 500 mg per day). The medicine is administered intravenously for 2 weeks. After this, they begin to gradually reduce the dosage.

Necrotizing pancreatitis is extremely severe. It is necessary to take up to 800 mg of medication per day or until the painful symptoms and shock completely disappear. After the patient's condition becomes stable, the dosage is gradually reduced. The medication is administered only after meals.

Analogs

Mexidol appeared on the domestic market relatively recently, but has already established itself due to its effectiveness and speed of action. However, its clinical studies have not yet been fully completed and continue to this day. If a drug does not give a good result over a certain period of time, then it is necessary to replace it with a drug of a similar composition and effect. The choice is made only by the doctor, based on the individual characteristics of the patient, the type of disease and its severity.

"Mexiprim" is an analogue of the Russian "Mexidol", produced in Germany. Mexiprim and Mexidol have the same active ingredient. The only difference is in the composition of the excipients. If you compare which is better - Mexidol or Mexiprim, then it is advisable to leave the choice to your doctor. Before you start using Mexiprim, you must carefully study the instructions for use.

In addition to Mexiprim, the medicine has many other analogues: Cavinton, Mildronate, Neurox, Cortexin, Nootropil and others.

As for Cavinton, it is not advisable to take it simultaneously with Mexidol. When used separately, both drugs give excellent results in therapeutic therapy. "Cavinton" gives a positive effect when trying to restore cerebral circulation, improve blood pressure, and restore the supply of oxygen to brain tissue. This drug is often used in the treatment of ophthalmological diseases and ENT organs.

"Neurox" is a complete analogue of "Mexidol", since it contains the same active component.

Mildronate is an effective vasodilator. With its help, you can quickly and effectively restore the supply of oxygen to brain tissue and improve blood supply. The medicine is often taken during the complex treatment of coronary artery disease. It lowers high blood pressure and has an effective effect on humoral and cellular immunity.

"Cortexin" is a drug created on the basis of an extract from the brain of cattle. It has a particularly powerful effect in the treatment of newborn patients with hypoxia of brain tissue.

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In Russia, every year there are from 5 to 10 million calls to emergency medical care for high blood pressure. But Russian heart surgeon Irina Chazova claims that 67% of hypertensive patients do not even suspect that they are sick!

How can you protect yourself and overcome the disease? One of the many recovered patients, Oleg Tabakov, told in his interview how to forget about hypertension forever.

Mexidol instructions for use. In this article we will get acquainted with the instructions on how to use the drug Mexidol® - what it helps with, its price and customer recommendations. From the instructions it is known that these are Mexidol tablets, film-coated 125 mg, Mexidol injections (in ampoules) 5% of the drug for the treatment of encephalopathies, TBI and other brain disorders in adults, children and pregnancy.

Excipients: lactose monohydrate - 97.5 mg, povidone - 25 mg, magnesium stearate - 2.5 mg.

Film shell composition: opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

• 10 pieces. - contour cellular packaging (1) - cardboard packs;
• 10 pieces. - contour cell packaging (2) - cardboard packs;
• 10 pieces. - contour cellular packaging (3) - cardboard packs;
• 10 pieces. - contour cell packaging (4) - cardboard packs;
• 10 pieces. - contour cell packaging (5) - cardboard packs.

Mexidol® - instructions for use

To optimize the functioning of the body, it is appropriate to take an additional course of prescribed medications. You should choose Mexidol if you need to influence the body’s resources, support the functions and tone of internal systems, especially the central nervous system. Unauthorized use of the drug is strictly contraindicated.

Compound

The active ingredient of Mexidol is ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate). An injection solution (50 g/l) or tablets containing 125 mg are available. active substance. This is a domestic drug and is one of the new generation of antioxidant drugs.

As excipients, the Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 liter). Mexidol tablets - excipients are magnesium stearate, sodium carboxymethylcellulose (otherwise known as carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Mexidol tablets instructions for use

Mexidol tablets are intended for oral administration. The daily dose varies from 375 to 750 mg, the frequency of doses is 3 (one or two tablets three times a day). The maximum permissible dose is 800 mg. per day, which corresponds to 6 tablets.

The duration of treatment depends on the disease and the patient’s body’s response to the prescribed treatment. As a rule, it ranges from two weeks to one and a half months. In cases where the drug is prescribed to relieve symptoms of alcohol withdrawal, the duration of the course is from five to seven days.

In this case, abrupt discontinuation of the drug is unacceptable: treatment is stopped gradually, reducing the dose over two to three days. At the beginning of the course, the patient is prescribed to take one or two tablets per dose, once or twice a day. The dose is gradually increased until a positive clinical effect is obtained (it should not exceed 6 tablets per day).

The duration of the therapeutic course in patients diagnosed with ischemic disease is from one and a half to two months. If necessary, a second course may be prescribed as prescribed by a doctor. The optimal time to prescribe a repeat course is autumn and spring.

What is Mexidol prescribed for - indications for use

Why is Mexidol prescribed? The drug is indicated for the treatment of:

1. Vegetative-vascular dystonia;
2. Alcohol and drug addiction;
3. Discirculatory encephalopathy;
4. Pathologies of the brain of an atherosclerotic nature;
5. Exposure to extreme (stress) factors;
6. Acute pathologies of cerebral circulation.

What is Mexidol taken for and what does it help with? Mexidol is indicated for the relief of: “Withdrawal syndrome” and various conditions that occur during oxygen deprivation.

Price for Mexidol

The cost of the drug is affordable to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately within the same price range.

It is important to read the instructions before purchasing. The price on the Internet is cheaper, real and positive recommendations from patients, high effectiveness of the drug. If you buy medicine at a pharmacy, the price depends on the city and region. No prescription required.

Directions for use and doses

Orally, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets).
Duration of treatment - 2 - 6 weeks; to relieve alcohol withdrawal - 5 - 7 days. Treatment is stopped gradually, reducing the dose over 2-3 days. Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets). The duration of therapy in patients with coronary heart disease is at least 1.5 - 2 months. Repeated courses (on the recommendation of a doctor) are preferably carried out in the spring and autumn periods.

pharmachologic effect

According to the instructions for use, Mexidol is characterized by a complex pharmacological effect, has antioxidant, adaptogenic, nootropic, membrane stabilizing, cerebroprotective, anxiolytic, vegetotropic, anticonvulsant effects:

• Restores the functions and structure of cell membranes, modulates membrane-bound enzymes, improves the interconnection of brain structures and synoptic transmission;
• Improves immune system function, inhibits platelet aggregation;
• Activates the synthesis of protein and nucleic acids inside cells, accelerates enzymatic reactions of the Krebs cycle and glucose utilization, promotes the synthesis of ATP and its accumulation inside cells;
• Improves cerebral hemodynamics, including microcirculation, has a positive effect on blood fluidity, limits the area of ​​cerebral ischemia and stimulates reparative processes;
• Reduces the level of low-density lipoproteins and cholesterol, promotes regression of atherosclerotic changes in blood vessels;
• Inhibits fat peroxidation, activates the antioxidant system, accelerates mitochondrial energy synthesis, and improves cellular energy metabolism.

Contraindications

1. Hypersensitivity to the drug;
2. Acute liver failure;
3. Acute renal failure.

Mexidol is not prescribed to children due to insufficient knowledge of the drug's effect.

Side effects

From the digestive system: individual adverse reactions of a dyspeptic or dyspeptic nature may occur.

Others: Allergic reactions are possible.

Overdose

Drug interactions

Mexidol can be combined with all drugs used to treat somatic diseases. When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants. Mexidol reduces the toxic effect of ethyl alcohol.

special instructions

Influence on the ability to drive vehicles and operate machinery. During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

For impaired renal function

The prescription drug is contraindicated in acute renal failure.

Mexidol injections instructions for use

The second form of release of this medicine is a solution for injection. If regular Mexidol is prescribed in this form, ampoules (injections) are also available without a prescription.

The release version is more effective, since the component - methylhydroxypyridine - immediately enters the systemic bloodstream, has a therapeutic effect, and gives a stable and long-lasting therapeutic effect. The medicine has antioxidant, nootropic, antihypoxic and anxiolytic properties. What does Mexidol help with? Indications for use are:

• Impaired cognitive function;
• Disturbed systemic circulation of the cerebral cortex and not only;
• Nervous disorders with panic attacks, anxiety;
• Open angle glaucoma;
• Insufficient nutrition of brain tissue.

The medication Mexidol injections according to the instructions is injected into the patient’s body into the muscle or intravenously. It is important to discuss single doses and course duration with your doctor in advance.

A similar summary of Mexidol instructions for use states that a single dose of medication depends on the nature of the pathological process, the degree of neglect of the diagnosed disease. These may be the following standards:

1. Traumatic brain injuries – 500 mg / 14 days;
2. Circulatory insufficiency in the cerebral cortex – 100-250 ml / 10 days;
3. Impaired cerebral circulation - 200-500 mg of medication / 14 days.
4. In the presence of mild cognitive impairment, older people inject about 300 mg/day into the muscle for up to thirty days;
5. Acute diseases of a purulent-inflammatory nature - from the first days of treatment and after the end of the operation. The required dosage is calculated by a specialist; the duration of use of the drug will depend on the form and severity of the disease. Features and characteristic features of its course. Mexidol is discontinued gradually, as soon as a stable clinical effect is achieved and blood counts stabilize;
6. For mild necrotizing pancreatitis - up to 200 mg three times a day. Choose one of the administration methods or use a combination of them;
7. For necrotizing pancreatitis, if it is severe, 800 mg is prescribed on the first day in a pulse dosage. For the following days, 200 to 500 mg is prescribed twice a day;
8. Encephalopathy (injections can only be done during the decompensation phase) - 200-400 mg of Mexidol intravenously twice a day for fourteen days. Over the next two weeks, about 200 mg are administered. 1 per day. A preventive measure occurs by administering a 250 mg solution intramuscularly. twice a day for two weeks;
9. In case of acute poisoning with neuroleptics, 300-500 mg/day is prescribed for a week;
10. For acute pancreatitis, accompanied by swelling, up to 500 mg of the drug Mexidol is prescribed 3 times a day by drip or injection into the muscle;
11. For alcohol withdrawal, 250 mg/daily is prescribed intravenously by drip or three injections into the muscle for one week.

The exact dosage of Mexidol should be selected by a doctor. Mexidol can be administered intravenously by drip. Another method of administration is jet. It is administered directly into a vein using a syringe.

There is no need to dilute this solution. The rate of administration of the ampoule is no more than seven minutes. If Mexidol is injected into a muscle, then it must be given in the center of the upper quadrant of the buttock.

Mexidol during pregnancy

The drug does not help expectant mothers recover quickly, but can only harm the intrauterine development of the fetus and provoke extensive pathologies. Clinical studies of such categories of patients have not been carried out, therefore the drug Mexidol is not prescribed during pregnancy. In addition, the medication is contraindicated during lactation.

Mexidol is contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug's effect.

Mexidol and alcohol compatibility

Mexidol instructions for use is an original drug that has a nootropic effect, so it is often used to eliminate withdrawal symptoms and symptoms of ethyl alcohol poisoning. Many people believe that if the drug is taken simultaneously with alcohol, the effect of the latter can be easily neutralized. But this is just an erroneous assumption.

As the substance penetrates the body, the process of stopping the existing pathology begins, while no protection is provided for the cells. Therefore, to the question of whether they can be used together, there is only one answer: it cannot, since there is no compatibility between the substances.

Disobedience in this regard can cause serious negative consequences in the form of nausea, vomiting, pain and dizziness. However, it is possible to use this drug as a single component in the phased elimination of alcohol dependence. Typically, this technique helps to increase the effectiveness of therapy and instantly eliminate disorders.

Thus, the drug is effective in eliminating numerous ailments and pathological phenomena, and therefore will allow you to recover from any form of many diseases in just a short course. But before using the medicine, it is recommended to consult a specialist.

Mexidol - analogues

If these injections give an allergic reaction, adjustment of the treatment regimen is necessary. Drugs similar in composition to Mexidol also act productively; the main thing is to choose the safest medication for a particular clinical picture. According to doctors' recommendations, Cerecard, Mexiprim, Mexidant, Neurox, Mexicor have proven themselves well.

Actovegin and Mexidol: The drugs have similar uses and are often prescribed together. Actovegin is produced on the basis of an extract from calf blood, so allergic reactions are more likely to develop to it. Improves nutrition and tissue regeneration. Unlike Mexidol, Actovegin is used for disorders in peripheral vessels, and to treat the consequences of such disorders - trophic ulcers and angiopathy.

What's better than Mexidol? Since the drug has recently appeared on the market, its research is ongoing. In the case of a particular patient, those remedies that give the maximum effect are always good. If there is no improvement within two to three days of using Mexidol, it is better to replace it with other drugs. There is no clear answer to the question of which drugs are better. The selection of a treatment regimen is individual and depends on the level of qualifications of the attending physician.

Mexidol or Mexiprim? Mexiprim is a German drug, similar in its properties to the domestic Mexidol. Produced by the Stada Arzneimittel concern. It differs only in the excipients included in the shell and core of the tablets.

Mexidol or Cavinton? The active ingredient of Cavinton is a semi-synthetic derivative of vincamine (devincan) contained in periwinkle - vinpocetine. It is a vasodilator used to improve blood circulation in the brain. Slightly reduces blood pressure, improves the supply of glucose and oxygen to the brain.

It is also used in ophthalmology and the treatment of age-related diseases of the ENT organs. Both drugs complement each other and are often used together in the treatment of cerebrovascular problems. It is not advisable to mix these drugs in one dropper; it is better to administer them separately.

Mexidol or Mildronate? Mildronate (trimethylhydrazinium propionate) is a vasodilator, improves oxygen supply to tissues, increases humoral and tissue immunity, lowers blood pressure, and is used in the treatment of coronary artery disease. It can be prescribed together with Mexidol for withdrawal symptoms and disorders of the blood supply to the brain, since the drugs complement each other.

Mexidol or Neurox? These two drugs are identical and contain the same active ingredient.

Mexidol or Cortexin? Cortexin contains an extract from bovine brain polypeptides. The choice of drug depends on the individual reaction of the patient’s body to it. Together, both drugs are used in the treatment of acute brain hypoxia in newborns. Prescribed only by the attending physician.

Mexidol or Nootropil? The active ingredient of Nootropil is piracetam. The drugs are often prescribed together to treat memory impairment, the consequences of ischemic stroke, alcoholism, and improving learning ability in children.

How to take Mexidol before or after meals is a question that worries patients in the first place. In order to avoid side effects, you must follow the instructions for use.

Abstract to the medicine

The instructions for the drug do not contain information about the compatibility of the active ingredients of the drug with food products. In this regard, Mexidol can be taken regardless of the food included in the daily menu. In addition, among the advantages of the drug, the following characteristics can be distinguished:

• no nausea after administration;
• well tolerated by patients;
• antioxidant effect on the body.

Indications for use

This medication can be recommended for use by specialists in various medical fields. As a rule, Mexidol should be taken if you have the following health problems:

• various consequences of brain accidents;
• head injuries;
• diseases associated with impaired vascular function;
• ischemia;
• neurological diseases;
• weakness, lethargy and general malaise.

In each case, a specialist, taking into account all the characteristics of the patient’s body, develops a course of treatment with which the most effective effect can be achieved. In addition, the doctor will advise how and at what time to take the tablets correctly - before or after meals.

Contraindications

Despite the wide range of effects, Mexidol cannot be taken by all patients. There are cases in which the use of the medication will not be beneficial and will not help cope with the disease:

• individual intolerance to components;
• pregnancy;
• lactation period;
• acute liver and kidney failure.

Application options and daily dose

The drug is available in 2 forms:

The dose of the drug, which is recommended for use during the day, is calculated individually in each case. It all depends on the patient’s age, the nature and stage of development of the disease. On average, a patient is recommended to take a dose of medication per day.

It is known that taking many medications on an empty stomach has a negative effect on the stomach and digestive system as a whole. To avoid this problem, Mexidol tablets should be taken after meals.

Similar drugs

There are a sufficient number of drugs whose composition is similar to Mexidol. Among its main substitutes are:

The drugs are produced in tablets or ampoules intended for injection.

In addition to the similarity in composition, there are medications that resemble Mexidol in the nature of their effect on the body:

How to take Mexidol tablets

The popular new generation drug Mexidol, which belongs to the group of new generation antioxidants, is designed to stop destructive processes in the human body. Therefore, you need to know how to take Mexidol tablets to restore and normalize metabolic processes in brain cells, so as not to harm the body.

Composition of the drug and scope of application

The active ingredient in Mexidol is ethylmethylhydroxypyridine succinate 125 mg, resulting in the following type of effect on the body:

• Hypoxia tolerance improves;
• Mental abilities and concentration improve;
• The body can more easily tolerate stressful situations of various types;
• The state of nervousness is relieved;
• The toxic effects of alcohol on the body are reduced;
• Blood circulation in the brain improves;
• Sleep, appetite and general condition of the body improves.

Mexidol tablets, according to the instructions attached to the drug, are indicated for use to prevent cell oxidation and stabilize the structure of intracellular membranes. Regular use of this drug prevents platelet aggregation, reduces cholesterol levels in the blood and prevents the development of degenerative processes, thereby slowing down the aging process of the body.

Release form

Mexidol is available on the pharmaceutical market in 2 dosage forms: tablets and ampoules.

For oral administration, the tablet form of this drug is used, biconvex in shape, in a white or cream-colored shell. Which are packaged in 10 pieces, in cell blisters.

To administer Mexidol intramuscularly or by infusion, the medicine is released in ampoules made of white or darkened glass. The solution, contained in an ampoule of 2–5 ml, is a colorless or slightly yellow liquid, odorless and contains 50 mg of ethylmethylhydroxypyridine succinate per 1 ml of solution. The drug is injected intramuscularly into the upper outer quadrant of the gluteal muscle.

Mexidol is stored in a dry, dark place, indoors with a maximum temperature increase of up to 25 ° C. If unpacked, Mexidol is stored for up to 3 years from the date of production indicated on the package.

Taking Mexidol and its dosage

Mexidol tablets should be taken one or two tablets 3 times a day, taking into account the individual tolerance of the drug, but without exceeding the maximum dose of 600 mg, most often the course of treatment with Mexidol takes into account taking the medication for 14 - 42 days. With a gradual exit from it, which involves a daily reduction in the daily dose of the drug.

Use of Mexidol for VSD

For vegetative-vascular dystonia, the drug is taken in tablets at a dose of 125–250 mg, up to 3 times a day, or according to a regimen drawn up by the attending physician, which takes into account the individual characteristics of the patient and allows to minimize side effects from the use of the drug.

If after taking the medicine the patient feels lethargic or persistent drowsiness, it is necessary to contact the attending physician to review the dosage of the medicine. To avoid negative consequences for the body, it is not recommended to stop taking the pills on your own.

After taking Mexilod, during the treatment of VSD, the patient experiences a significant improvement in the psychological state, aggressiveness disappears, the feeling of depression and oppression goes away, and recovery from a depressive state is accelerated.

Relieving alcohol withdrawal

To relieve alcohol withdrawal syndrome, it is better to take Mexidol tablets for 7 days, as a continuation of treatment, after a course of intramuscular injections. The doctor independently, based on the individual characteristics of the patient’s body, selects the dosage of the drug for the patient and prescribes a regimen for taking the pills. The medicine entering the patient’s body quickly relieves withdrawal symptoms, restores the psycho-emotional background, improves memory and promotes rapid cleansing of the body when ingesting ethanol.

Cerebral circulatory disorders

In case of circulatory disorders in the brain, an intravenous course of the drug is prescribed, which is administered for 10-14 days 2-4 times a day, in a volume not exceeding 500 mg, by drip method. After which, for 2 weeks the medicine is administered by intramuscular injection, 2-3 times a day, 200-250 mg of the drug.

Upon completion of the main stage of therapeutic treatment, the patient may be prescribed oral administration of the drug for prophylactic purposes. To find out how to drink Mexidol, you need to consult your doctor.

Medicines with a similar spectrum of action

Mexidol is an original medicinal product with a patented active ingredient; its analogues on the pharmaceutical market are:

And other not so widespread medications. Despite the fact that the medicine is not cheap, in order to avoid unwanted side effects, it is not recommended to independently replace it with analogue drugs that have similar therapeutic characteristics.

Side effect of Mexidol, with uncontrolled use

Uncontrolled oral intake of Mexidol can provoke the following undesirable sensations: heartburn, nausea, headache, belching, general physical weakness, upset stomach. In extremely rare cases, Mexidol can provoke a decrease in blood pressure, impaired motor coordination and emotional hyperreactivity.

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Mexidol ® tablets

PRESCRIPTION MEDICINES ARE PRESCRIBED TO THE PATIENT ONLY BY A DOCTOR. THIS INSTRUCTION IS FOR MEDICAL PROFESSIONALS ONLY.

INSTRUCTIONS for medical use of the drug Mexidol ®

Registration number: LSR/07 dated 08/09/2007

Trade name of the drug: Mexidol

Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form: film-coated tablets

Active substance: ethylmethylhydroxypyridine succinate mg, excipients: lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description: Tablets are round, biconvex, film-coated, from white to white with a creamy tint.

Pharmacotherapeutic group: antioxidant agent.

Pharmacological properties:

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics (neuroleptics)). The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes. The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins. The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol has a pronounced antitoxic effect in withdrawal symptoms. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Rapidly absorbed when taken orally. The maximum concentration at mg doses is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in urine immediately after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuron conjugates. Tx/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. Rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications for use:

Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;

Mild traumatic brain injury, consequences of traumatic brain injury;

Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);

Autonomic dystonia syndrome;

Mild cognitive disorders of atherosclerotic origin;

Anxiety disorders in neurotic and neurosis-like conditions;

Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;

Conditions after acute intoxication with antipsychotic drugs;

Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;

Impact of extreme (stress) factors.

Contraindications:

Acute liver and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Directions for use and dosage:

Orally, mg 3 times a day; maximum daily dose of zamg (6 tablets). Duration of treatment: week; for relief of alcohol withdrawal days. Treatment is stopped gradually, reducing the dose over the course of days. The initial dose is 50 mg (1 - 2 tablets) once a day with a gradual increase until a therapeutic effect is obtained. Maximum daily dose of mg (6 tablets).

Side effect:

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Interaction with other drugs:

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

Special instructions:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose:

In case of overdose, drowsiness may develop.

Release form: Film-coated tablets, 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each along with instructions for use per pack. For hospital use Film-coated tablets 125 mg. 450 and 900 tablets in a plastic jar made of food grade plastic along with instructions for use in corrugated cardboard boxes.

Storage conditions: List B. Store in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life: 3 years. Do not use after the expiration date indicated on the pack.

Dispensing conditions: By prescription

A: ZiO-Zdorovye CJSC, Moscow region, Podolsk, st. Zheleznodorozhnaya 2

B: CJSC ALSI-Pharma, CJSC ALSI Pharma, Moscow, Trifonovsky deadlock, 3,

Organization receiving claims: LLC NPK Pharmasoft, Moscow, st. Avtozavodskaya, 22